Lipid-coated superparamagnetic nanoparticles for thermoresponsive cancer treatment.
Autor: | Allam AA; James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA; Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt., Potter SJ; James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA., Bud'ko SL; Department of Physics and Astronomy, Iowa State University, Ames, IA 50011, USA., Shi D; Department of Mechanical and Materials Engineering, University of Cincinnati, Cincinnati, OH 45221, USA., Mohamed DF; Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt., Habib FS; Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt., Pauletti GM; James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA. Electronic address: gm.pauletti@uc.edu. |
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Jazyk: | angličtina |
Zdroj: | International journal of pharmaceutics [Int J Pharm] 2018 Sep 05; Vol. 548 (1), pp. 297-304. Date of Electronic Publication: 2018 Jul 05. |
DOI: | 10.1016/j.ijpharm.2018.07.022 |
Abstrakt: | Poor aqueous solubility, chemical instability, and indiscriminate cytotoxicity have limited clinical development of camptothecin (CPT) as potent anticancer therapeutic. This research aimed at fabricating thermoresponsive nanocomposites that enhance solubility and stability of CPT in aqueous milieu and enable stimulus-induced drug release using magnetic hyperthermia. 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and l-α-dipalmitoylphosphatidyl glycerol (DPPG) (1:1, mol/mol) were immobilized on the surface of superparamagnetic Fe (Copyright © 2018 Elsevier B.V. All rights reserved.) |
Databáze: | MEDLINE |
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