Normal liver tissue change after proton beam therapy.

Autor: Fukumitsu N; Proton Medical Research Center, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, 305-8575, Japan. fukumitsu@pmrc.tsukuba.ac.jp., Takahashi S; Proton Medical Research Center, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, 305-8575, Japan., Okumura T; Proton Medical Research Center, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, 305-8575, Japan., Ishida T; Proton Medical Research Center, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, 305-8575, Japan., Murofushi KN; Proton Medical Research Center, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, 305-8575, Japan., Ohnishi K; Proton Medical Research Center, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, 305-8575, Japan., Aihara T; Proton Medical Research Center, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, 305-8575, Japan., Ishikawa H; Proton Medical Research Center, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, 305-8575, Japan., Tsuboi K; Proton Medical Research Center, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, 305-8575, Japan., Sakurai H; Proton Medical Research Center, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, 305-8575, Japan.
Jazyk: angličtina
Zdroj: Japanese journal of radiology [Jpn J Radiol] 2018 Sep; Vol. 36 (9), pp. 559-565. Date of Electronic Publication: 2018 Jul 06.
DOI: 10.1007/s11604-018-0757-9
Abstrakt: Purpose: Normal liver tissue changes after proton beam therapy (PBT) were investigated in patients at 1 and 2 years after the therapy.
Materials and Methods: Changes in normal liver tissue volume were examined. The dose distribution of the normal liver tissue was also simulated on the follow-up CTs.
Results: The normal liver tissue volume was 1149 ± 215 cm 3 before treatment, 1089 ± 188 cm 3 at 1 year, and 1080 ± 236 cm 3 at 2 years after treatment. The normal liver tissue volume was increased in 10 and decreased in 20 patients at 2 years and was smaller than that before the treatment in total (P = 0.03). The simulated volume that received more than 30 Gray equivalent [V30 (cm 3 )] at 1 year was 258 ± 187 cm 3 and that at 2 years (244 ± 171 cm 3 ) was smaller than that before treatment (297 ± 140 cm 3 ) (P = 0.03).
Conclusions: The changes in the shape and volume of normal liver tissue are not constant, which cause a large dose distribution discrepancy in the normal liver for 2 years. Therefore, careful consideration of the dose distribution of normal liver tissue is required when planning re-irradiation.
Databáze: MEDLINE
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