18 F-NaF and 18 F-FDG as molecular probes in the evaluation of atherosclerosis.

Autor: McKenney-Drake ML; Department of Health Sciences, Butler University, Indianapolis, IN, USA., Moghbel MC; Department of Radiology, Stanford University Medical Center, Stanford, CA, USA., Paydary K; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA., Alloosh M; Department of Cellular & Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN, USA., Houshmand S; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA., Moe S; Department of Medicine, Indiana University School of Medicine and Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA., Salavati A; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.; Department of Radiology, University of Minnesota, Minneapolis, MN, USA., Sturek JM; Department of Medicine, University of Virginia, Charlottesville, VA, USA., Territo PR; Department of Radiology & Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA., Weaver C; Department of Nutrition Science, Purdue University, West Lafayette, IN, USA., Werner TJ; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA., Høilund-Carlsen PF; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark., Sturek M; Department of Cellular & Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN, USA., Alavi A; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA. abass.alavi@uphs.upenn.edu.
Jazyk: angličtina
Zdroj: European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2018 Nov; Vol. 45 (12), pp. 2190-2200. Date of Electronic Publication: 2018 Jul 06.
DOI: 10.1007/s00259-018-4078-0
Abstrakt: The early detection of atherosclerotic disease is vital to the effective prevention and management of life-threatening cardiovascular events such as myocardial infarctions and cerebrovascular accidents. Given the potential for positron emission tomography (PET) to visualize atherosclerosis earlier in the disease process than anatomic imaging modalities such as computed tomography (CT), this application of PET imaging has been the focus of intense scientific inquiry. Although 18 F-FDG has historically been the most widely studied PET radiotracer in this domain, there is a growing body of evidence that 18 F-NaF holds significant diagnostic and prognostic value as well. In this article, we review the existing literature on the application of 18 F-FDG and 18 F-NaF as PET probes in atherosclerosis and present the findings of original animal and human studies that have examined how well 18 F-NaF uptake correlates with vascular calcification and cardiovascular risk.
Databáze: MEDLINE
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