Testicular histopathology, semen analysis and FSH, predictive value of sperm retrieval: supportive counseling in case of reoperation after testicular sperm extraction (TESE).

Autor: Gnessi L; Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Policlinico Umberto I, 00161, Rome, Italy. lucio.gnessi@uniroma1.it., Scarselli F; Centre for Reproductive Medicine, European Hospital, Rome, Italy., Minasi MG; Centre for Reproductive Medicine, European Hospital, Rome, Italy., Mariani S; Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Policlinico Umberto I, 00161, Rome, Italy., Lubrano C; Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Policlinico Umberto I, 00161, Rome, Italy., Basciani S; Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Policlinico Umberto I, 00161, Rome, Italy., Greco PF; Centre for Reproductive Medicine, European Hospital, Rome, Italy., Watanabe M; Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Policlinico Umberto I, 00161, Rome, Italy., Franco G; Department Gynaecological-Obstetrical and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161, Rome, Italy., Farcomeni A; Department of Public Health and Infectious Diseases, 'Sapienza' University of Rome, Rome, Italy., Greco E; Centre for Reproductive Medicine, European Hospital, Rome, Italy.
Jazyk: angličtina
Zdroj: BMC urology [BMC Urol] 2018 Jul 04; Vol. 18 (1), pp. 63. Date of Electronic Publication: 2018 Jul 04.
DOI: 10.1186/s12894-018-0379-7
Abstrakt: Background: To provide indicators for the likelihood of sperm retrieval in patients undergoing testicular sperm extraction is a major issue in the management of male infertility by TESE. The aim of our study was to determine the impact of different parameters, including testicular histopathology, on sperm retrieval in case of reoperation in patients undergoing testicular sperm extraction.
Methods: We retrospectively analyzed 486 patients who underwent sperm extraction for intracytoplasmic sperm injection and testicular biopsy. Histology was classified into: normal spermatogenesis; hypospermatogenesis (reduction in the number of normal spermatogenetic cells); maturation arrest (absence of the later stages of spermatogenesis); and Sertoli cell only (absence of germ cells). Semen analysis and serum FSH, LH and testosterone were measured.
Results: Four hundred thirty patients had non obstructive azoospermia, 53 severe oligozoospermia and 3 necrozoospermia. There were 307 (63%) successful sperm retrieval. Higher testicular volume, lower levels of FSH, and better histological features were predictive for sperm retrieval. The same parameters and younger age were predictive factors for shorter time for sperm recovery. After multivariable analysis, younger age, better semen parameters, better histological features and lower values of FSH remained predictive for shorter time for sperm retrieval while better semen and histology remained predictive factors for successful sperm retrieval. The predictive capacity of a score obtained by summing the points assigned for selected predictors (1 point for Sertoli cell only, 0.33 points for azoospermia, 0.004 points for each FSH mIU/ml) gave an area under the ROC curve of 0.843.
Conclusions: This model can help the practitioner with counseling infertile men by reliably predicting the chance of obtaining spermatozoa with testicular sperm extraction when a repeat attempt is planned.
Databáze: MEDLINE
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