Efficacy-safety of Facilitated Subcutaneous Immunoglobulin in Immunodeficiency Due to Hematological Malignancies. A Single-Center Retrospective Analysis.

Autor:	Dimou M; 1st Propaedeutic Clinic, Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece msdimou@gmail.com., Iliakis T; 1st Propaedeutic Clinic, Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece., Maltezas D; 1st Propaedeutic Clinic, Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece., Bitsani A; 1st Propaedeutic Clinic, Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece., Kalyva S; 1st Propaedeutic Clinic, Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece., Koudouna A; 1st Propaedeutic Clinic, Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece., Kotsanti S; 1st Propaedeutic Clinic, Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece., Petsa P; 1st Propaedeutic Clinic, Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece., Papaioannou P; 1st Propaedeutic Clinic, Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece., Kyrtsonis MC; 1st Propaedeutic Clinic, Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece., Panayiotidis P; 1st Propaedeutic Clinic, Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
Jazyk:	angličtina
Zdroj:	Anticancer research [Anticancer Res] 2018 Jul; Vol. 38 (7), pp. 4187-4191.
DOI:	10.21873/anticanres.12712
Abstrakt:	Background/aim: Hematological malignancies are frequently complicated by secondary immunodeficiency (SID). Immunoglobulin replacement with intravenous gamma globulins (IVIg) reduces infection incidence, antibiotics' need and hospitalization days in these patients. Facilitated subcutaneous immunoglobulin replacement (fSCIg) has been studied in primary immunodeficiency patients and is equally efficacious with several advantages (self-administration, same bioavailability, long infusion intervals, fewer adverse drug reactions). fSCIg has been less extensively studied in SID. We present our retrospective single-center data of fSCIg administration to hematological patients with SID, focusing on efficacy and safety issues. Patients and Methods: Overall, 33 hematological patients with hypogammaglobulinemia were treated with fSCIg according to ESMO 2015 guidelines, between mid-October 2015 and mid-January 2018 in our Department. Results: The infection rate was very low (18.1%). Shorter infusion intervals further reduced it. ADRs were rare (9%) and mild (grade 1). fSCIg managed to reduce the everyday nursery/hospital burden of our tertiary hospital. Conclusion: fSCIg compares favorably to IVIg replacement in SID patients. (Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
Databáze:	MEDLINE
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