Thoracoabdominal asynchrony and paradoxical motion in middle stage amyotrophic lateral sclerosis.

Autor: Sarmento A; PneumoCardioVascular Lab, Hospital Universitário Onofre Lopes, Empresa Brasileira de Serviços Hospitalares (EBSERH), Universidade Federal do Rio Grande do Norte, Brazil., Fregonezi G; PneumoCardioVascular Lab, Hospital Universitário Onofre Lopes, Empresa Brasileira de Serviços Hospitalares (EBSERH), Universidade Federal do Rio Grande do Norte, Brazil., Dourado-Junior MET; Ambulatório de Neurologia, EBSERH, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Aliverti A; Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Italy., de Andrade AD; Departamento de Fisioterapia, Universidade Federal do Pernambuco, Pernambuco, Brazil., Parreira VF; Departamento de Fisioterapia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Resqueti V; PneumoCardioVascular Lab, Hospital Universitário Onofre Lopes, Empresa Brasileira de Serviços Hospitalares (EBSERH), Universidade Federal do Rio Grande do Norte, Brazil. Electronic address: vanessaresqueti@hotmail.com.
Jazyk: angličtina
Zdroj: Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2019 Jan; Vol. 259, pp. 16-25. Date of Electronic Publication: 2018 Jun 30.
DOI: 10.1016/j.resp.2018.06.012
Abstrakt: Aim: To assess thoracoabdominal asynchrony (TAA) and the presence of paradoxical motion in middle stage amyotrophic lateral sclerosis (ALS) and its relationships with chest wall tidal volume (V T,CW ), breathing pattern and cough peak flow (CPF).
Methods: Phase angle (θ) between upper (RCp) and lower ribcage (RCa) and abdomen (AB), as well as percentage of inspiratory time for the lower ribcage (IP RCa ) and abdomen (IP AB ) moving in opposite directions were quantified using optoelectronic plethysmography in 12 ALS patients during quiet breathing and coughing. Paradoxical motion of the compartments was based on threshold values of θ and IP, obtained in twelve age and sex matched healthy persons.
Results: During quiet breathing, significantly higher RCa and AB θ (p < .05), IP RCa (p = 0.001) and IP AB (p < 0.05) were observed in ALS patients as compared to controls. In ALS patients, correlations between RCa and AB θ with forced vital capacity (FVC) (r=-0.773, p < 0.01), vital capacity (r=-0.663, p < 0.05) and inspiratory capacity (IC) (r=-0.754, p < 0.01), as well as between RCp and RCa θ with FVC (r=-0.608, p < 0.05) and CPF (r=-0.601, p < 0.05) were found. During coughing, correlations between RCp and AB θ with CPF (r=-0.590, p < 0.05), IC (r=-0.748, p < 0.01) and V T,CW (r=-0.608, p < 0.05), as well as between RCa and AB θ with CPF (r=-0.670, p < 0.05), IC (r=-0.713, p < 0.05) and peak expiratory flow (r=-0.727, p < 0.05) were also observed in ALS patients. ALS patients with paradoxical motion presented lower vital capacity and FVC %pred (p < 0.05) compared to those without paradoxical motion.
Conclusions: Middle stage ALS patients exhibit TAA and paradoxical motion during quiet spontaneous breathing and coughing. In addition, diaphragmatic weakness (i.e. decrease in excursion of the RCa and AB compartments) was observed earlier in the lower ribcage rather than the abdominal compartment in this population.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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