Medication Use During Pregnancy and Lactation in a Dutch Population.

Autor:	de Waard M; 1 Department of Pediatrics, VU University Medical Center, Amsterdam, the Netherlands., Blomjous BS; 1 Department of Pediatrics, VU University Medical Center, Amsterdam, the Netherlands., Hol MLF; 1 Department of Pediatrics, VU University Medical Center, Amsterdam, the Netherlands.; 2 Department of Oral and Maxillofacial Surgery, Academic Medical Center, Amsterdam, the Netherlands., Sie SD; 1 Department of Pediatrics, VU University Medical Center, Amsterdam, the Netherlands., Corpeleijn WE; 1 Department of Pediatrics, VU University Medical Center, Amsterdam, the Netherlands.; 3 Department of Pediatrics, Emma Children's Hospital, Academic Medical Center, Amsterdam, the Netherlands., van Goudoever JHB; 1 Department of Pediatrics, VU University Medical Center, Amsterdam, the Netherlands.; 3 Department of Pediatrics, Emma Children's Hospital, Academic Medical Center, Amsterdam, the Netherlands., van Weissenbruch MM; 1 Department of Pediatrics, VU University Medical Center, Amsterdam, the Netherlands.
Jazyk:	angličtina
Zdroj:	Journal of human lactation : official journal of International Lactation Consultant Association [J Hum Lact] 2019 Feb; Vol. 35 (1), pp. 154-164. Date of Electronic Publication: 2018 Jul 03.
DOI:	10.1177/0890334418775630
Abstrakt:	Background:: Medication use during pregnancy and lactation can be unavoidable, but knowledge on safety for the fetus or breastfed infant is limited among patients and healthcare providers. Research Aim:: This study aimed to determine (a) the prevalence of medication use in pregnant and lactating women in a tertiary academic center, (b) the types and safety of these medicines, and (c) the influence of medication use on initiation of breastfeeding. Methods:: This study used a cross-sectional survey among women ( N = 292) who underwent high-risk or low-risk deliveries. Data about their use of prescribed, over-the-counter, and homeopathic medication during pregnancy were obtained through a structured interview, followed by a questionnaire during lactation. Safety was classified according to the risk classification system from the Dutch Teratological Information Service. Results:: Overall, 95.5% of participants used medication. One third of participants used at least one medicine with an unknown risk for the fetus. Teratogenic medication was used by 6.5% of participants, whereas 29.5% used medication with a (suspected) pharmacological effect on the fetus. Lactation was initiated by 258 (88.7%) participants, of which 84.2% used medication while breastfeeding. In 3.8% of participants, this medication was classified unsafe, but none used medication with an unknown risk. One-third of the nonlactating participants decided not to initiate breastfeeding because of medication use. In 70% of participants, this decision was appropriate. Conclusion:: The prevalence of overall use of medication in Dutch pregnant and lactating women admitted to a tertiary center was high. There is an urgent need for pharmacometric studies for determination of the safe use of the most frequently used medicines during pregnancy or lactation.
Databáze:	MEDLINE
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