Transition-Metal-Free Approach for the Synthesis of 4-Aryl-quinolines from Alkynes and Anilines.

Autor:	Phanindrudu M; Division of Organic Synthesis and Process Chemistry , CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.; Academy of Scientific & Innovative Research (AcSIR) , New Delhi 110001 , India., Wakade SB; Division of Organic Synthesis and Process Chemistry , CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.; Academy of Scientific & Innovative Research (AcSIR) , New Delhi 110001 , India., Tiwari DK; Division of Organic Synthesis and Process Chemistry , CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.; Academy of Scientific & Innovative Research (AcSIR) , New Delhi 110001 , India., Likhar PR; Inorganic and Physical Chemistry Division , CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.; Academy of Scientific & Innovative Research (AcSIR) , New Delhi 110001 , India., Tiwari DK; Division of Organic Synthesis and Process Chemistry , CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.; Academy of Scientific & Innovative Research (AcSIR) , New Delhi 110001 , India.
Jazyk:	angličtina
Zdroj:	The Journal of organic chemistry [J Org Chem] 2018 Aug 17; Vol. 83 (16), pp. 9137-9143. Date of Electronic Publication: 2018 Jul 12.
DOI:	10.1021/acs.joc.8b01204
Abstrakt:	An efficient and transition-metal-free approach for the synthesis of 4-arylquinolines from readily available anilines and alkynes in the presence of K 2 S 2 O 8 and DMSO has been developed. A variety of alkynes and anilines having a diverse range of substitution patterns can undergo the one-pot cascade process successfully. Effectively, this method uses DMSO as one carbon source, thus providing a highly atom-economical and environmentally benign approach for the synthesis of 4-arylquinolines.
Databáze:	MEDLINE
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