| Autor: |
Giorno TBS; Universidade Federal do Rio de Janfeiro, Instituto de Ciências Biomédicas, Laboratório de Farmacologia da Dor e da Inflamação, Rio de Janeiro, Brazil., Moreira IGDS; Universidade Federal do Rio de Janeiro, Instituto de Química, Laboratório de Aromas, Rio de Janeiro, Brazil., Rezende CM; Universidade Federal do Rio de Janeiro, Instituto de Química, Laboratório de Aromas, Rio de Janeiro, Brazil., Fernandes PD; Universidade Federal do Rio de Janfeiro, Instituto de Ciências Biomédicas, Laboratório de Farmacologia da Dor e da Inflamação, Rio de Janeiro, Brazil. patricia.dias@icb.ufrj.br. |
| Jazyk: |
angličtina |
| Zdroj: |
Scientific reports [Sci Rep] 2018 Jul 03; Vol. 8 (1), pp. 10027. Date of Electronic Publication: 2018 Jul 03. |
| DOI: |
10.1038/s41598-018-28355-4 |
| Abstrakt: |
The present study examined the potential antinociceptive activity of C18 5-HT ( β N-octadecanoyl-5-hydroxytryptamide) using chemical and thermal nociception models in mice. Orally administered C18 5-HT (0.1, 1 and 10 mg/kg) produced significant dose-dependent antinociceptive effects in formalin-, capsaicin- and glutamate-induced licking models. This compound also induced a significant increase in the response to thermal stimuli in the hot plate test, and its antinociceptive effect was not related to muscle relaxant or sedative actions. In a thermal hyperalgesia model, C18 5-HT presented an anti-hyperalgesic profile as evidenced by the increase in the response time of the animals. Furthermore, intraperitoneal (i.p) pretreatment with naloxone (a non-selective opioid receptor antagonist, 1 mg/kg), ondansetron (serotoninergic receptor antagonist (5-HT3 subtype), 0.5 mg/kg) or AM241 (CB1 cannabinoid receptor antagonist, 1 mg/kg) reversed the antinociceptive effects of C18 5-HT in the hot plate model. In the formalin-induced licking model, pretreatment with naloxone reversed the antinociceptive effects of C18 5-HT, as demonstrated by an increase in the paw licking response when compared with the C18 5-HT-treated group. These findings suggest that C18 5-HT has peripheral and central antinociceptive effects and that its mechanism of action involves, ate least in part, opioid, serotoninergic and cannabinoid pathways. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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