Role of selenium and vitamin C in mitigating oxidative stress induced by fenitrothion in rat liver.

Autor: Milošević MD; University of Kragujevac, Faculty of Science, Department of Biology and Ecology, Kragujevac, Serbia. Electronic address: marijam@kg.ac.rs., Paunović MG; University of Kragujevac, Faculty of Science, Department of Biology and Ecology, Kragujevac, Serbia. Electronic address: milica.paunovic@pmf.kg.ac.rs., Matić MM; University of Kragujevac, Faculty of Science, Department of Biology and Ecology, Kragujevac, Serbia. Electronic address: milosmatic@kg.ac.rs., Ognjanović BI; University of Kragujevac, Faculty of Science, Department of Biology and Ecology, Kragujevac, Serbia. Electronic address: branka@kg.ac.rs., Saičić ZS; University of Belgrade, Institute for Biological Research 'Siniša Stanković', Belgrade, Serbia. Electronic address: zorica.saicic@ibiss.bg.ac.rs.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2018 Oct; Vol. 106, pp. 232-238. Date of Electronic Publication: 2018 Jun 28.
DOI: 10.1016/j.biopha.2018.06.132
Abstrakt: Excessive use of organophosphate insecticides, including fenitrothion (FNT) can cause detrimental consequences in non-target organisms. Selenium (Se) and vitamin C (Vit C) possess protective abilities against various toxic compounds due to their antioxidative properties. Accordingly, the aim of the present study was to examine the possible ameliorative effects of Se and Vit C in hepatotoxicity induced by FNT. For the purpose of this study, male Wistar albino rats were divided into control and groups treated with Se (0.5 mg/kg b.w, as Na 2 SeO 3 ) and Vit C (100 mg/kg b.w), FNT (20 mg/kg b.w) and FNT in cotreatment with Se and Vit C for 30 days. The current data showed a reduction in absolute and relative liver weight after FNT administration. Increased activities of liver enzymes (AST, ALT, ALP, LDH and GGT) indicated liver damage. FNT alone caused significant alterations in biochemical parameters (glucose and total bilirubin). Elevation in LPO level along with decreased activities of antioxidant enzymes (SOD, CAT, GSH-Px) and GSH content reflected the presence of oxidative stress. Coadministration of FNT with Se and Vit C exhibited hepatoprotective role confirmed by reduction of oxidative stress levels and restoration in the values of examined parameters. Because of their beneficial effects, Se and Vit C may be used in reducing injuries caused by pesticides.
(Copyright © 2018 Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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