Two sides of a coin: GG genotype of C7 provides protection against fibrosis severity while showing a higher risk for hepatocellular carcinoma in patients with hepatitis C.

Autor: de Lima RE; Institute of Biological Sciences/ICB-UPE, University of Pernambuco, Brazil; Institute Aggeu Magalhães/IAM-FIOCRUZ-PE, Brazil., de Holanda Martins CM; Institute of Biological Sciences/ICB-UPE, University of Pernambuco, Brazil., do Carmo RF; Federal University of São Francisco Valley, UNIVASF, Brazil., Aroucha DCBL; Institute of Liver and Transplantation of Pernambuco/IFP, Brazil; Faculty of Medical Sciences/FCM-UPE, University of Pernambuco, Brazil., Pereira LMMB; Institute of Liver and Transplantation of Pernambuco/IFP, Brazil; Faculty of Medical Sciences/FCM-UPE, University of Pernambuco, Brazil., Vasconcelos LRS; Institute Aggeu Magalhães/IAM-FIOCRUZ-PE, Brazil; Institute of Liver and Transplantation of Pernambuco/IFP, Brazil. Electronic address: luydson.vasconcelos@cpqam.fiocruz.br., Moura P; Institute of Biological Sciences/ICB-UPE, University of Pernambuco, Brazil.
Jazyk: angličtina
Zdroj: Human immunology [Hum Immunol] 2018 Sep; Vol. 79 (9), pp. 702-707. Date of Electronic Publication: 2018 Jun 30.
DOI: 10.1016/j.humimm.2018.06.009
Abstrakt: The complement system (CS) is a key element of immunity against pathogens but also seems to influence other events, such as tumorigenesis and tissue repair. Complement component 7 (C7) is a key component of the lytic pathway of CS, leading to the formation of the membrane attack complex (MAC). This study aimed to investigate the existence of the association of a polymorphism in the C7 gene, rs1063499, with hepatic fibrosis and the occurrence of hepatocellular carcinoma (HCC) in patients with hepatitis C. We analyzed 456 samples from patients with chronic hepatitis C. Real-time PCR was used for allelic discrimination. Patients were classified by their METAVIR score as F1 (n = 100), F2 (n = 83), F3 (n = 101) or F4 (n = 66); 106 patients were diagnosed with HCC. Patients carrying the G/G genotype of C7 had a lower chance of developing severe fibrosis in the recessive model (p = 0.042; OR: 0.65 95% CI 0.41-1.02). However, the G/G genotype frequency was higher in patients with HCC (P = 0.01; OR: 2.07 95% CI 1.20-3.53) and in those with larger tumors (p = 0.04). The G/G C7 genotype seems to be a protective factor against advanced fibrosis; however, it was associated with a higher risk of HCC and the occurrence of larger hepatic nodules, suggesting the involvement of C7 in the physiopathogenesis of HCC and fibrosis in patients with hepatitis C virus (HCV).
(Copyright © 2018 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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