Attentional ERPs distinguish aging and early Alzheimer's dementia.

Autor: Lockwood CT; Departments of Neurology, Brain and Cognitive Sciences, Ophthalmology, The Center for Visual Science, The University of Rochester Medical Center, Rochester, NY 14642-0673, USA., Vaughn W; Departments of Neurology, Brain and Cognitive Sciences, Ophthalmology, The Center for Visual Science, The University of Rochester Medical Center, Rochester, NY 14642-0673, USA., Duffy CJ; Departments of Neurology, Brain and Cognitive Sciences, Ophthalmology, The Center for Visual Science, The University of Rochester Medical Center, Rochester, NY 14642-0673, USA. Electronic address: Charles_Duffy@urmc.rochester.edu.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2018 Oct; Vol. 70, pp. 51-58. Date of Electronic Publication: 2018 Jun 06.
DOI: 10.1016/j.neurobiolaging.2018.05.022
Abstrakt: The early detection of Alzheimer's disease requires our distinguishing it from cognitive aging. Here, we test whether spatial attentional changes might support that distinction. We engaged young normal (YN), older normal (ON), and patients with early Alzheimer's dementia (EAD) in an attentionally cued, self-movement heading discrimination task while we recorded push-button response times and event related potentials. YNs and ONs show the behavioral effects of attentional shifts from the cue to the target, whereas EAD patients did not (p < 0.001). YNs and ONs also show the shifting lateralization of a newly described attentional event related potentials component, whereas EAD patients did not (p < 0.001). Our findings suggest that spatial inattention in EAD patients may contribute to heading direction processing impairments that distinguish them from ONs and undermine their navigational capacity and driving safety.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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