Bacteria and viruses in the nasopharynx immediately prior to onset of acute lower respiratory infections in Indigenous Australian children.

Autor: Smith-Vaughan HC; Menzies School of Health Research, Charles Darwin University, Building 58, Royal Darwin Hospital, Rocklands Drive, Darwin, Northern Territory, 0810, Australia. Heidi.Smith-Vaughan@menzies.edu.au.; School of Medicine, Griffith University, Gold Coast, 4222, Australia. Heidi.Smith-Vaughan@menzies.edu.au., Binks MJ; Menzies School of Health Research, Charles Darwin University, Building 58, Royal Darwin Hospital, Rocklands Drive, Darwin, Northern Territory, 0810, Australia., Beissbarth J; Menzies School of Health Research, Charles Darwin University, Building 58, Royal Darwin Hospital, Rocklands Drive, Darwin, Northern Territory, 0810, Australia., Chang AB; Menzies School of Health Research, Charles Darwin University, Building 58, Royal Darwin Hospital, Rocklands Drive, Darwin, Northern Territory, 0810, Australia.; Lady Cilento Children's Hospital, Queensland University of Technology, Brisbane, 4101, Australia., McCallum GB; Menzies School of Health Research, Charles Darwin University, Building 58, Royal Darwin Hospital, Rocklands Drive, Darwin, Northern Territory, 0810, Australia., Mackay IM; Faculty of Medicine, Child Health Research Centre, The University of Queensland, Brisbane, 4101, Australia.; Department of Health, Public and Environmental Health Virology Laboratory, Forensic and Scientific Services, Archerfield, 4108, Australia., Morris PS; Menzies School of Health Research, Charles Darwin University, Building 58, Royal Darwin Hospital, Rocklands Drive, Darwin, Northern Territory, 0810, Australia.; Royal Darwin Hospital, Darwin, 0810, Australia., Marsh RL; Menzies School of Health Research, Charles Darwin University, Building 58, Royal Darwin Hospital, Rocklands Drive, Darwin, Northern Territory, 0810, Australia., Torzillo PJ; Royal Prince Alfred Hospital, Sydney, 2050, Australia., Wurzel DF; Murdoch Childrens Research Institute, The Royal Children's Hospital, Melbourne, 3052, Australia., Grimwood K; School of Medicine, Griffith University, Gold Coast, 4222, Australia.; Menzies Health Institute Queensland, Griffith University, Gold Coast, 4222, Australia.; Departments of Infectious Disease and Paediatrics, Gold Coast Health, Gold Coast, 4215, Australia., Nosworthy E; Menzies School of Health Research, Charles Darwin University, Building 58, Royal Darwin Hospital, Rocklands Drive, Darwin, Northern Territory, 0810, Australia., Gaydon JE; QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia., Leach AJ; Menzies School of Health Research, Charles Darwin University, Building 58, Royal Darwin Hospital, Rocklands Drive, Darwin, Northern Territory, 0810, Australia., MacHunter B; Menzies School of Health Research, Charles Darwin University, Building 58, Royal Darwin Hospital, Rocklands Drive, Darwin, Northern Territory, 0810, Australia., Chatfield MD; Menzies School of Health Research, Charles Darwin University, Building 58, Royal Darwin Hospital, Rocklands Drive, Darwin, Northern Territory, 0810, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia., Sloots TP; UQ Centre for Child Health Research, The University of Queensland, Brisbane, 4101, Australia., Cheng AC; Department of Infectious Diseases, Alfred Health, Melbourne, 3004, Australia. Allen.Cheng@monash.edu.; School of Public Health and Preventive Medicine, Monash University, Melbourne, 3800, Australia. Allen.Cheng@monash.edu.
Jazyk: angličtina
Zdroj: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2018 Sep; Vol. 37 (9), pp. 1785-1794. Date of Electronic Publication: 2018 Jun 29.
DOI: 10.1007/s10096-018-3314-7
Abstrakt: Acute lower respiratory infection (ALRI) is a major cause of hospitalization for Indigenous children in remote regions of Australia. The associated microbiology remains unclear. Our aim was to determine whether the microbes present in the nasopharynx before an ALRI were associated with its onset. A retrospective case-control/crossover study among Indigenous children aged up to 2 years. ALRI cases identified by medical note review were eligible where nasopharyngeal swabs were available: (1) 0-21 days before ALRI onset (case); (2) 90-180 days before ALRI onset (same child controls); and (3) from time and age-matched children without ALRI (different child controls). PCR assays determined the presence and/or load of selected respiratory pathogens. Among 104 children (182 recorded ALRI episodes), 120 case-same child control and 170 case-different child control swab pairs were identified. Human adenoviruses (HAdV) were more prevalent in cases compared to same child controls (18 vs 7%; OR = 3.08, 95% CI 1.22-7.76, p = 0.017), but this association was not significant in cases versus different child controls (15 vs 10%; OR = 1.93, 95% CI 0.97-3.87 (p = 0.063). No other microbes were more prevalent in cases compared to controls. Streptococcus pneumoniae (74%), Haemophilus influenzae (75%) and Moraxella catarrhalis (88%) were commonly identified across all swabs. In a pediatric population with a high detection rate of nasopharyngeal microbes, HAdV was the only pathogen detected in the period before illness presentation that was significantly associated with ALRI onset. Detection of other potential ALRI pathogens was similar between cases and controls.
Databáze: MEDLINE
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