The late positive potential and subjective arousal ratings evoked by negative images vary as a function of oxytocin receptor genotype SNP rs53576.

Autor: Fowler JJ; Departments of Psychology., Braley KL; Departments of Psychology., Farero RD; Neuroscience Program, University of Washington, Seattle, Washington, USA., Russell ET; Departments of Psychology., Phiel CJ; Integrative Biology, University of Colorado-Denver, Denver., Kisley MA; Department of Psychology, University of Colorado, Colorado Springs, Colorado., Albeck DS; Departments of Psychology.
Jazyk: angličtina
Zdroj: Neuroreport [Neuroreport] 2018 Sep 26; Vol. 29 (14), pp. 1145-1150.
DOI: 10.1097/WNR.0000000000001085
Abstrakt: In the central nervous system the neuropeptide oxytocin mediates a range of behaviors related primarily to emotionality. One factor that influences oxytocinergic communication in the human brain and correlates with emotional behaviors is the single nucleotide polymorphism rs53576 on the oxytocin receptor gene (OXTR). For example, variations in this OXTR genotype are related to parental, altruistic, and other prosocial behaviors. Electroencephalographic waveforms of visually evoked response potentials recorded at the midline parietal electrode site display a prominent component putatively involved with attention allocation called the late positive potential. The magnitude of the late positive potential was found to be significantly higher in homozygous G allele individuals compared with A allele carriers when viewing negative emotionally charged images. Inversely, A allele carriers rated these negative images as more arousing, when measured by the Self-Assessment Manikin rating scale. These data suggest that OXTR functioning contributes to visual processing and subjective experience of negative stimuli.
Databáze: MEDLINE