| Autor: |
Watthey JW, Stanton JL, Desai M, Babiarz JE, Finn BM |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 1985 Oct; Vol. 28 (10), pp. 1511-6. |
| DOI: |
10.1021/jm00148a023 |
| Abstrakt: |
Syntheses of the potent angiotensin converting enzyme inhibitor (3S)-1-(carboxymethyl)-3-[[(1S)-1-carboxy-3-phenylpropyl]amino]- 2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one (4b; CGS 14831) and the related monoester prodrug (17a; CGS 14824A) are described together with preparative details for six- and eight-membered ring analogues. Inhibitory potencies and in vivo biological activity of the compounds are discussed. The data indicate that 17a has a biological profile comparable to that of enalapril. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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