| Autor: |
Emerson SR; Department of Food, Nutrition, Dietetics, and Health and., Kurti SP; Department of Kinesiology, Physical Activity and Nutrition Clinical Research Consortium, Kansas State University, Manhattan, KS., Teeman CS; Department of Food, Nutrition, Dietetics, and Health and., Emerson EM; Department of Food, Nutrition, Dietetics, and Health and., Cull BJ; Department of Food, Nutrition, Dietetics, and Health and., Haub MD; Department of Food, Nutrition, Dietetics, and Health and., Rosenkranz SK; Department of Food, Nutrition, Dietetics, and Health and. |
| Jazyk: |
angličtina |
| Zdroj: |
Current developments in nutrition [Curr Dev Nutr] 2017 Mar 22; Vol. 1 (4), pp. e000232. Date of Electronic Publication: 2017 Mar 22 (Print Publication: 2017). |
| DOI: |
10.3945/cdn.116.000232 |
| Abstrakt: |
Background: A substantial increase in triglycerides (TGs) after a meal is associated with an increased risk of cardiovascular disease. Most studies investigating the effects of a meal on TGs have not used meals that reflect typical consumption. Objective: The objective of this study was to compare the TG and inflammatory responses of true-to-life meals, containing moderate fat and energy contents, with a high-fat, high-energy, low-carbohydrate meal (HFM) typically used to test TG responses. Methods: Nine healthy, insufficiently active men [mean ± SD age: 25.1 ± 6.7 y; body mass index (in kg/m 2 ): 25.8 ± 7.0; <150 min moderate- to vigorous-intensity physical activity/wk] completed 3 meal trials in random order: an HFM (17 kcal/kg, 60% fat), a moderate-fat meal (MFM; 8.5 kcal/kg, 30% fat), and a biphasic meal (BPM), in which participants consumed the full MFM at baseline and 3 h postmeal. Blood samples were collected via an indwelling catheter at baseline and hourly for 6 h. Results: Peak blood TGs were significantly greater ( P = 0.003) after the HFM (285.2 ± 169.7 mg/dL) than after the MFM (156.0 ± 98.7 mg/dL), but the BPM (198.3 ± 182.8 mg/dL) was not significantly different from the HFM ( P = 0.06) or the MFM ( P = 0.99). Total area under the curve for TGs was greater after the HFM (1348.8 ± 783.7 mg/dL × 6 h) than after the MFM (765.8 ± 486.8 mg/dL × 6 h; P = 0.0005) and the BPM (951.8 ± 787.7 mg/dL × 6 h; P = 0.03), although the MFM and BPM were not significantly different ( P = 0.72). There was a significant time-by-meal interaction for interferon γ, but not for interleukins 6, 8, or 10. Conclusion: These findings in insufficiently active, healthy young men suggest that the large TG response after HFMs in previous studies may not reflect the metabolic state of many individuals in daily life. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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