Trends in hip fracture in patients with rheumatoid arthritis: results from the Spanish National Inpatient Registry over a 17-year period (1999-2015). TREND-AR study.

Autor:	Mazzucchelli R; Department of Rheumatology, Hospital Universitario Fundación Alcorcón, Madrid, Spain., Pérez Fernandez E; Department of Clinical Research, Hospital Universitario Fundación Alcorcón, Madrid, Spain., Crespí-Villarías N; Centro de Salud La Rivota (Alcorcón), Madrid, Spain., Quirós-Donate J; Department of Rheumatology, Hospital Universitario Fundación Alcorcón, Madrid, Spain., García Vadillo A; Department of Rheumatology, Hospital Universitario de la Princesa, Madrid, Spain., Espinosa M; Department of Rheumatology, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain., Peña M; Department of Rehabilitation, Hospital Universitario Fundación Alcorcón, Madrid, Spain., Macía-Villa C; Department of Rheumatology, Hospital Universitario Severo Ochoa, Madrid, Spain., Morell-Hita JL; Department of Rheumatology, Hospital Universitario Ramón y Cajal, Madrid, Spain., Martinez-Prada C; Department of Rheumatology, Hospital Universitario Clínico San Carlos, Madrid, Spain., Villaverde V; Department of Rheumatology, Hospital Universitario de Móstoles, Madrid, Spain., Morado Quiroga I; Department of Rheumatology, Hospital Universitario Clínico San Carlos, Madrid, Spain., Guzón-Illescas O; Department of Rehabilitation, Hospital Universitario Fundación Alcorcón, Madrid, Spain., Barbadillo C; Department of Rheumatology, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain., Fernández Prada M; Department of Rheumatology, Hospital Universitario de Guadalajara, Guadalajara, Spain., Godoy H; Department of Rheumatology, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain., Herranz Varela A; Department of Rheumatology, Hospital Universitario del Henares, Madrid, Spain., Galindo Izquierdo M; Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain., Rodriguez Caravaca G; Department of Preventive Medicine and Public Health, Universidad Rey Juan Carlos I, Madrid, Spain.
Jazyk:	angličtina
Zdroj:	RMD open [RMD Open] 2018 Jun 04; Vol. 4 (1), pp. e000671. Date of Electronic Publication: 2018 Jun 04 (Print Publication: 2018).
DOI:	10.1136/rmdopen-2018-000671
Abstrakt:	Purpose: To analyse trends in hip fracture (HF) rates in patients with rheumatoid arthritis (RA) over an extended time period (17 years). Methods: This observational retrospective survey was performed by reviewing data from the National Surveillance System for Hospital Data, which includes more than 98% of Spanish hospitals. All hospitalisations of patients with RA and HF that were reported from 1999 to 2015 were analysed. Codes were selected using the Ninth International Classification of Diseases, Clinical Modification: ICD-9-CM: RA 714.0 to 714.9 and HF 820.0 to 820.3. The crude and age-adjusted incidence rate of HF was calculated by age and sex strata over the last 17 years. General lineal models were used to analyse trends. Results: Between 1999 and 2015, 6656 HFs occurred in patients with RA of all ages (84.25% women, mean age 77.5 and 15.75% men, mean age 76.37). The age-adjusted osteoporotic HF rate was 221.85/100 000 RA persons/ year (women 227.97; men 179.06). The HF incidence rate increased yearly by 3.1% (95% CI 2.1 to 4.0) during the 1999-2015 period (p<0.001) and was more pronounced in men (3.5% (95% CI 2.1 to 4.9)) than in women (3.1% (95% CI 2.3 to 4.1)). The female to male ratio decreased from 1.54 in 1999 to 1.14 in 2015. The average length of hospital stays (ALHS) decreased (p<0.001) from 16.76 days (SD 15.3) in 1999 to 10.78 days (SD 7.72) in 2015. Age at the time of hospitalisation increased (p<0.001) from 75.3 years (SD 9.33) in 1999 to 79.92 years (SD 9.47) in 2015. There was a total of 326 (4.9%) deaths during admission, 247 (4.4%) in women and 79 (7.5%) in men (p<0.001). Conclusion: In Spain, despite the advances that have taken place in controlling disease activity and in treating osteoporosis, the incidence rate of HF increased in both male and female patients with RA. Competing Interests: Competing interests: None declared.
Databáze:	MEDLINE
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