Relapse of acute myeloid leukemia after allogeneic stem cell transplantation is associated with gain of WT1 alterations and high mutation load.

Autor: Vosberg S; Experimental Leukemia and Lymphoma Research, Department of Medicine III, University Hospital, LMU Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Germany., Hartmann L; Experimental Leukemia and Lymphoma Research, Department of Medicine III, University Hospital, LMU Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Germany., Metzeler KH; Experimental Leukemia and Lymphoma Research, Department of Medicine III, University Hospital, LMU Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Germany., Konstandin NP; Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Germany., Schneider S; Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Germany.; Institute of Human Genetics, University Hospital, LMU Munich, Germany., Varadharajan A; Laboratory for Functional Genome Analysis, Gene Center, LMU Munich, Germany., Hauser A; Laboratory for Functional Genome Analysis, Gene Center, LMU Munich, Germany., Krebs S; Laboratory for Functional Genome Analysis, Gene Center, LMU Munich, Germany., Blum H; Laboratory for Functional Genome Analysis, Gene Center, LMU Munich, Germany., Bohlander SK; Leukaemia and Blood Cancer Research Unit, Department of Molecular Medicine and Pathology, The University of Auckland, New Zealand., Hiddemann W; Experimental Leukemia and Lymphoma Research, Department of Medicine III, University Hospital, LMU Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Germany., Tischer J; Hematopoietic Stem Cell Transplantation, Department of Medicine III, University Hospital, LMU Munich, Germany., Spiekermann K; Experimental Leukemia and Lymphoma Research, Department of Medicine III, University Hospital, LMU Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Germany., Greif PA; Experimental Leukemia and Lymphoma Research, Department of Medicine III, University Hospital, LMU Munich, Germany pgreif@med.uni-muenchen.de.; German Cancer Consortium (DKTK), partner site Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Germany.
Jazyk: angličtina
Zdroj: Haematologica [Haematologica] 2018 Dec; Vol. 103 (12), pp. e581-e584. Date of Electronic Publication: 2018 Jun 28.
DOI: 10.3324/haematol.2018.193102
Databáze: MEDLINE