| Autor: |
Mikropoulou EV; Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece. elenamik@pharm.uoa.gr., Vougogiannopoulou K; Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece. nadia_voug@pharm.uoa.gr., Kalpoutzakis E; Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece. elkalp@pharm.uoa.gr., Sklirou AD; Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15784 Athens, Greece. asklirou@biol.uoa.gr., Skaperda Z; Department of Biochemistry and Biotechnology, University of Thessaly, 41221 Larissa, Greece. zoskaper@bio.uth.gr., Houriet J; Phytochemistry and Bioactive Natural Products, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, CMU-Rue Michel-Servet 1, 1206 Geneva, Switzerland. Joelle.Houriet@unige.ch., Wolfender JL; Phytochemistry and Bioactive Natural Products, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, CMU-Rue Michel-Servet 1, 1206 Geneva, Switzerland. Jean-Luc.Wolfender@unige.ch., Trougakos IP; Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15784 Athens, Greece. itrougakos@biol.uoa.gr., Kouretas D; Department of Biochemistry and Biotechnology, University of Thessaly, 41221 Larissa, Greece. dkouret@uth.gr., Halabalaki M; Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece. mariahal@pharm.uoa.gr., Mitakou S; Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece. mitakou@pharm.uoa.gr. |
| Abstrakt: |
Wild or semi-wild edible greens (chórta) are an integral part of the traditional Greek Mediterranean diet due to their nutritional value, containing various phytonutrients beneficial to human health. Water-based decoctions of chórta are widely consumed in Greek alternative medicine as health promoting agents. This study examined the chemical profile of the decoctions of eight edible plants, Cichorium intybus , C. endivia , C. spinosum , Crepis sancta , Sonchus asper , Carthamus lanatus , Centaurea raphanina , and Amaranthus blitum , by UPLC-ESI-HRMS and HRMS/MS analysis, to determine possibly bioactive constituents. The profiles of the plants from the Asteraceae family are dominated by the presence of phenolic acids and flavonoid derivatives, whereas the A. blitum decoction is rich in triterpene saponins. Interestingly, the Centaurea raphanina decoction was found to be extremely rich in flavanones, particularly in the aglycone pinocembrin. Further phytochemical investigation and fractionation of this extract resulted in the isolation and identification of five compounds: phlorin ( 1 ), syringin ( 2 ), pinocembrin ( 3 ), pinocembroside ( 4 ), and pinocembrin-7- O -neohesperidoside ( 5 ). The extracts were also tested for their antioxidant and differential cytotoxic activity against tumor cells. C. raphanina was found to be differentially toxic against metastatic tumor cells. In conclusion, we found that Greek edible greens are a rich source of bioactive secondary metabolites and their consumption could contribute to the maintenance of overall health. |
