| Autor: |
Murashko TO, Simirnov IV, Bondarev AA, Ivanov AA, Postnikov PS, Nemtsev AO, Udut VV |
| Jazyk: |
English; Russian |
| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2016 Aug; Vol. 79 (4), pp. 26-28. |
| Abstrakt: |
We have evaluated the anti-inflammatory activity of the sodium salt of 4-(O-β-D-glucopyranosyloxy)benzoic acid in comparison to well-known nonsteroidal anti-inflammatory drugs (NSAIDs). Carrageenan suspension (1%, 0.1 mL) was injected into subplantar region of the right hindpaw of rats (n = 12) pretreated (7 days and 60 min before carrageenan injection) intragastrically with methyl ester of 4(β-D-glucopyranosyloxy)benzoic acid (20 mg/kg), acetylsalicylic acid (20 mg/kg), 4-hydroxybenzoic acid (20 mg/kg), or vehicle (2 mL of purified water). Paw edema volume was measured plethysmographically at 1, 2 and 4 h after carrageenan injection. The results showed that intragastric administration of the sodium salt of 4-(O-β-D-glucopyranosyloxy)benzoic acid in a dose of 20 mg/kg for 7 days decreased the intensity of experimental inflammation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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