STUDYING THE PHYSICAL DEPENDENCE ON AND TOLERANCE TO THE ANTINOCICEPTIVE EFFECT OF RU-1205 SUBSTANCE.

Autor: Grechko OY, Shtareva DM, Spasov AA, Litvinov LA, Rashchenko AI
Jazyk: English; Russian
Zdroj: Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2016 Aug; Vol. 79 (4), pp. 8-11.
Abstrakt: We have studied the physical dependence on and tolerance to the analgesic activity of compound RU-1205. It is established that this compound does not cause side effects typical of morphine and butorphanol including the development of withdrawal syndrome upon naloxone provocation and tolerance to analgesic activity upon 14-day administration.
Databáze: MEDLINE