Micro RNA clusters in maternal plasma are associated with preterm birth and infant outcomes.

Autor: Wommack JC; Microgen Laboratories, La Marque, TX, United States of America., Trzeciakowski JP; Texas A&M University, College of Medicine, Bryan, TX, United States of America., Miranda RC; Texas A&M University, College of Medicine, Bryan, TX, United States of America., Stowe RP; Microgen Laboratories, La Marque, TX, United States of America., Ruiz RJ; Microgen Laboratories, La Marque, TX, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2018 Jun 27; Vol. 13 (6), pp. e0199029. Date of Electronic Publication: 2018 Jun 27 (Print Publication: 2018).
DOI: 10.1371/journal.pone.0199029
Abstrakt: The current study examined micro RNA (miRNAs) clusters from the maternal plasma to determine their association with preterm birth (PTB) and infant birth outcomes. A subsample of 42 participants who spontaneously delivered either preterm (≤37 weeks) or term was selected from a parent sample of 515 pregnant Mexican American women. Plasma samples and prenatal data were collected at a single mid-gestation time point (22-24 weeks' gestation) and birth outcomes were obtained from medical records after delivery. Circulating miRNAs were analyzed by qPCR. When miRNAs were grouped according to chromosomal cluster rather than expression level, individual miRNAs correlated strongly with other individual miRNAs within their respective genomic locus. miRNAs from the c19mc cluster negatively correlated with c14mc miRNAs, and this relationship was more pronounced in PTB. Clusters c14mc was negatively associated with length of gestation; while the c19mc was positively associated with length of gestation and infant head circumference. Together, these findings suggest that groups of miRNAs from common chromosomal clusters, rather than individual miRNAs, operate as co-regulated groups of signaling molecules to coordinate length of gestation and infant outcomes. From this evidence, differences in cluster-wide expression of miRNAs are involved in spontaneous PTB.
Competing Interests: We have the following interests. Raymond P. Stowe is employed by Microgen Laboratories LLC., while Joel C. Wommack and Jeanne Ruiz have unpaid appointments at Microgen. Raymond P. Stowe, Joel C. Wommack and Jeanne Ruiz have intellectual property on PTB diagnostic methods. There are no patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.
Databáze: MEDLINE
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