A Case of Bullous Pemphigoid: A Prevalent and Potentially Fatal Condition.
| Autor: | Parellada J; Internal Medicine, Orlando Regional Medical Center., Olivera Arencibia Y; Internal Medicine, Orlando Regional Medical Center., Watson H; Internal Medicine, Orlando Regional Medical Center., Parellada N; School of Medicine, Geisinger Commonwealth School of Medicine., Saikaly LE; Department of Psychology, University of Florida, Gainsville., Saikaly SK; College of Medicine, University of Central Florida College of Medicine. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2018 Apr 25; Vol. 10 (4), pp. e2533. Date of Electronic Publication: 2018 Apr 25. |
| DOI: | 10.7759/cureus.2533 |
| Abstrakt: | Bullous pemphigoid is the most common of the blistering disorders. It is most commonly found in the elderly and is diagnosed based on clinical, histologic, and immunologic criteria. It presents clinically with diffuse eczematous, pruritic, urticaria-like lesions, with the later appearance of tense bullae or blistering lesions typically filled with clear fluid. Histologically, a sub-epidermal blister is seen and immunofluorescence shows immunoglobulin G antibodies directed against the structural components of the keratinocytic hemidesmosomal proteins BP180 and BP230. Multiple treatment modalities are present for this condition, including anti-inflammatory medications, medications that reduce antibody formation, and treatments to increase the elimination of antibodies. The aim of this case report is to present a classic case of this condition, to highlight an awareness of differing treatment options, and to advocate referral to a dermatologist given its potential severity. Competing Interests: The authors have declared that no competing interests exist. |
| Databáze: | MEDLINE |
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