18 F-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques.

Autor: Hop H; Division of Vascular Medicine, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands. h.hop@umcg.nl., de Boer SA; Division of Vascular Medicine, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands., Reijrink M; Division of Vascular Medicine, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands., Kamphuisen PW; Division of Vascular Medicine, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands., de Borst MH; Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Pol RA; Division of Vascular Surgery, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Zeebregts CJ; Division of Vascular Surgery, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Hillebrands JL; Division of Pathology, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Slart RHJA; Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Biomedical Photonic Imaging, University of Twente, Enschede, The Netherlands., Boersma HH; Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Doorduin J; Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Mulder DJ; Division of Vascular Medicine, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
Jazyk: angličtina
Zdroj: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology [J Nucl Cardiol] 2019 Aug; Vol. 26 (4), pp. 1064-1075. Date of Electronic Publication: 2018 Jun 25.
DOI: 10.1007/s12350-018-1325-5
Abstrakt: Background: 18 F-NaF positron emission tomography (PET) targets microcalcifications. We compared in vitro microPET assessed 18 F-NaF uptake between culprit and non-culprit human carotid plaques. Furthermore, we compared 18 F-NaF uptake with calcification visualized on microcomputed tomography (microCT).
Methods: Carotid plaques from stroke patients undergoing surgery were incubated in 18 F-NaF and scanned using a microPET and a microCT scan. The average PET assessed 18 F-NaF uptake was expressed as percentage of the incubation dose per gram (%Inc/g). 18 F-NaF PET volume of interest (VOI) was compared with CT calcification VOI.
Results: 23 carotid plaques (17 culprit, 6 non-culprit) were included. The average 18 F-NaF uptake in culprit carotid plaques was comparable with the uptake in non-culprit carotid plaques (median 2.32 %Inc/g [IQR 1.98 to 2.81] vs. median 2.35 %Inc/g [IQR 1.77 to 3.00], P = 0.916). Only a median of 10% (IQR 4 to 25) of CT calcification VOI showed increased 18 F-NaF uptake, while merely a median of 35% (IQR 6 to 42) of 18 F-NaF PET VOI showed calcification on CT.
Conclusions: 18 F-NaF PET represents a different stage in the calcification process than CT. We observed a similar PET assessed 18 F-NaF uptake and pattern in culprit and non-culprit plaques of high-risk patients, indicating that this method may be of more value in early atherosclerotic stenosis development.
Databáze: MEDLINE
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