Cancer Metabolism: Current Understanding and Therapies.
| Autor: | Counihan JL; Departments of Chemistry, Molecular and Cell Biology, and Nutritional Sciences and Toxicology , University of California, Berkeley , Berkeley , California 94720 , United States., Grossman EA; Departments of Chemistry, Molecular and Cell Biology, and Nutritional Sciences and Toxicology , University of California, Berkeley , Berkeley , California 94720 , United States., Nomura DK; Departments of Chemistry, Molecular and Cell Biology, and Nutritional Sciences and Toxicology , University of California, Berkeley , Berkeley , California 94720 , United States. |
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| Jazyk: | angličtina |
| Zdroj: | Chemical reviews [Chem Rev] 2018 Jul 25; Vol. 118 (14), pp. 6893-6923. Date of Electronic Publication: 2018 Jun 25. |
| DOI: | 10.1021/acs.chemrev.7b00775 |
| Abstrakt: | Dysregulation of cancer cell metabolism contributes to abnormal cell growth, the biological end point of cancer. We review here numerous affected oncogenes and metabolic pathways common in cancer and how they contribute to cancer pathogenesis and malignancy. This review also discusses various pharmacological manipulations that take advantage of these metabolic abnormalities and the current targeted therapies that have arisen from this research. |
| Databáze: | MEDLINE |
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