Polymorphism of FAS and FAS Ligand Genes in Alopecia Areata: A Case-control Study in Egyptian Population.

Autor: Seleit I; Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufiya University, Egypt., Bakry OA; Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufiya University, Egypt., Gayed EAE; Department of Medical Biochemistry, Faculty of Medicine, Menoufiya University, Egypt., Gawad AED; Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufiya University, Egypt.
Jazyk: angličtina
Zdroj: Indian journal of dermatology [Indian J Dermatol] 2018 May-Jun; Vol. 63 (3), pp. 220-226.
DOI: 10.4103/ijd.IJD_286_17
Abstrakt: Background: Alopecia areata (AA) is a common dermatologic disease with suspected autoimmune etiology. Tumor necrosis factor superfamily member 6 or CD95 (FAS) and FAS ligand (FASL) are proapoptotic proteins. The relationship between apoptosis and autoimmunity is well recognized. Inflammatory T cells in AA are cytotoxic and possess FAS/FASL antigens.
Aim: This study aims to investigate the association between FAS-670 A/G and FASL-124 A/G gene polymorphisms and AA to clarify if these polymorphisms influence disease occurrence or increase disease risk.
Materials and Methods: A case-control study was conducted on sixty patients with AA, and 40 age- and sex-matched healthy subjects, as a control group. Disease severity was assessed by severity of alopecia tool (SALT) Score. FAS 670A/G and FASL 124A/G gene polymorphisms were investigated by the restriction fragment length polymorphism polymerase chain reaction.
Results: For FAS gene, G/G genotype was significantly higher in cases than in control group with odds ratio 5.1. G allele was more prevalent among patient group with odds ratio 1.75. For FASL gene, A/G genotype was significantly higher in cases than in control group with odds ratio 4.53. G allele was more prevalent among patient group with odds ratio 1.88. GG genotype of FAS was significantly associated with longer disease duration ( P =0.001), recurrent attacks ( P =0.01), higher SALT score ( P =0.009), alopecia universalis ( P =0.002), and severe disease ( P =0.006).
Conclusion: FAS and FASL gene polymorphisms are associated with AA. Further large-scale studies on different ethnicities are required for more clarification of their role in disease development. Therapeutic modalities based on their inhibition could be promising in the treatment of a common disease like AA.
Competing Interests: There are no conflicts of interest. What is new? This is the first study to report an association between FAS-670 A/G and FASL-124 A/G gene polymorphism and AA in Egyptian population.GG genotype of FAS is associated with longer disease duration, recurrent attacks, higher SALT score, alopecia universalis, and severe disease.
Databáze: MEDLINE
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