HDAC6 at Crossroads of Infection and Innate Immunity.

Autor: Moreno-Gonzalo O; Cell-Cell Communication Laboratory, Vascular Pathophysiology Area, Centro Nacional Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, Madrid 28029, Spain; Servicio de Inmunología, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Universidad Autónoma de Madrid, Diego de León 62, Madrid 28006, Spain., Mayor F Jr; Departamento de Biología Molecular, Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), Universidad Autónoma de Madrid, Madrid 28049, Spain; CIBER de Enfermedades Cardiovasculares, ISCIII (CIBERCV), 28029 Madrid, Spain., Sánchez-Madrid F; Cell-Cell Communication Laboratory, Vascular Pathophysiology Area, Centro Nacional Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, Madrid 28029, Spain; Servicio de Inmunología, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Universidad Autónoma de Madrid, Diego de León 62, Madrid 28006, Spain; CIBER de Enfermedades Cardiovasculares, ISCIII (CIBERCV), 28029 Madrid, Spain. Electronic address: fsmadrid@salud.madrid.org.
Jazyk: angličtina
Zdroj: Trends in immunology [Trends Immunol] 2018 Aug; Vol. 39 (8), pp. 591-595. Date of Electronic Publication: 2018 Jun 21.
DOI: 10.1016/j.it.2018.05.004
Abstrakt: Histone deacetylase 6 (HDAC6) acts by enzyme-dependent and -independent mechanisms to regulate diverse cellular processes including autophagy, the ubiquitin proteasome system, and cell migration. HDAC6 also has emerging roles in innate immunity, including pathogen sensing and destruction, thus placing this enzyme at the crossroads of infection and innate immunity.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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