In-house cyclotron production of high-purity Tc-99m and Tc-99m radiopharmaceuticals.

Autor: Martini P; Legnaro Laboratories, Italian National Institute for Nuclear Physics (INFN), Legnaro, Padua, Italy; Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy. Electronic address: petra.martini@unife.it., Boschi A; Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy. Electronic address: alessandra.boschi@unife.it., Cicoria G; Nuclear Medicine S. Orsola Hospital, Bologna, Italy., Zagni F; Nuclear Medicine S. Orsola Hospital, Bologna, Italy., Corazza A; Nuclear Medicine S. Orsola Hospital, Bologna, Italy., Uccelli L; Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy., Pasquali M; Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy., Pupillo G; Legnaro Laboratories, Italian National Institute for Nuclear Physics (INFN), Legnaro, Padua, Italy., Marengo M; Nuclear Medicine S. Orsola Hospital, Bologna, Italy., Loriggiola M; Legnaro Laboratories, Italian National Institute for Nuclear Physics (INFN), Legnaro, Padua, Italy., Skliarova H; Legnaro Laboratories, Italian National Institute for Nuclear Physics (INFN), Legnaro, Padua, Italy., Mou L; Legnaro Laboratories, Italian National Institute for Nuclear Physics (INFN), Legnaro, Padua, Italy., Cisternino S; Legnaro Laboratories, Italian National Institute for Nuclear Physics (INFN), Legnaro, Padua, Italy., Carturan S; Department of Physics and Astronomy, University of Padua, Italy., Melendez-Alafort L; Veneto Institute of Oncology IOV-IRSS, Padua, Italy., Uzunov NM; Legnaro Laboratories, Italian National Institute for Nuclear Physics (INFN), Legnaro, Padua, Italy., Bello M; Department of Physics and Astronomy, University of Padua, Italy., Alvarez CR; Legnaro Laboratories, Italian National Institute for Nuclear Physics (INFN), Legnaro, Padua, Italy., Esposito J; Legnaro Laboratories, Italian National Institute for Nuclear Physics (INFN), Legnaro, Padua, Italy., Duatti A; Legnaro Laboratories, Italian National Institute for Nuclear Physics (INFN), Legnaro, Padua, Italy; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy.
Jazyk: angličtina
Zdroj: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2018 Sep; Vol. 139, pp. 325-331. Date of Electronic Publication: 2018 May 30.
DOI: 10.1016/j.apradiso.2018.05.033
Abstrakt: In the last years, the technology for producing the important medical radionuclide technetium-99m by cyclotrons has become sufficiently mature to justify its introduction as an alternative source of the starting precursor [ 99m Tc][TcO 4 ] - ubiquitously employed for the production of 99m Tc-radiopharmaceuticals in hospitals. These technologies make use almost exclusively of the nuclear reaction 100 Mo(p,2n) 99m Tc that allows direct production of Tc-99m. In this study, it is conjectured that this alternative production route will not replace the current supply chain based on the distribution of 99 Mo/ 99m Tc generators, but could become a convenient emergency source of Tc-99m only for in-house hospitals equipped with a conventional, low-energy, medical cyclotron. On this ground, an outline of the essential steps that should be implemented for setting up a hospital radiopharmacy aimed at the occasional production of Tc-99m by a small cyclotron is discussed. These include (1) target production, (2) irradiation conditions, (3) separation/purification procedures, (4) terminal sterilization, (5) quality control, and (6) Mo-100 recovery. To address these issues, a comprehensive technology for cyclotron-production of Tc-99m, developed at the Legnaro National Laboratories of the Italian National Institute of Nuclear Physics (LNL-INFN), will be used as a reference example.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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