Cigarette smoke extract acts directly on CD4 T cells to enhance Th1 polarization and reduce memory potential.

Autor: Tejero JD; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA., Armand NC; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA., Finn CM; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA., Dhume K; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA., Strutt TM; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA., Chai KX; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA., Chen LM; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA., McKinstry KK; Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA. Electronic address: kai.mckinstry@ucf.edu.
Jazyk: angličtina
Zdroj: Cellular immunology [Cell Immunol] 2018 Sep; Vol. 331, pp. 121-129. Date of Electronic Publication: 2018 Jun 18.
DOI: 10.1016/j.cellimm.2018.06.005
Abstrakt: Although cigarette smoke is known to alter immune responses, whether and how CD4 T cells are affected is not well-described. We aimed to characterize how exposure to cigarette smoke extract impacts CD4 T cell effector generation in vitro under Th1-polarizing conditions. Our results demonstrate that cigarette smoke directly acts on CD4 T cells to impair effector expansion by decreasing division and increasing apoptosis. Furthermore, cigarette smoke enhances Th1-associated cytokine production and increases expression of the transcription factor T-bet, the master regulator of Th1 differentiation. Finally, we show that exposure to cigarette smoke extract during priming impairs the ability of effectors to form memory cells. Our findings thus demonstrate that cigarette smoke simultaneously enhances effector functions but promotes terminal differentiation of CD4 T cell effectors. This study may be relevant to understanding how smoking can both aggravate autoimmune symptoms and reduce vaccine efficacy.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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