Accuracy of the HPV status site-specific factor 10 (SSF-10) variable for patients with oropharyngeal cancers in the Iowa Cancer Registry, 2010-2014.

Autor: Kahl AR; University of Iowa College of Public Health & the Iowa Cancer Registry, Iowa City, Iowa., Charlton ME; University of Iowa College of Public Health & the Iowa Cancer Registry, Iowa City, Iowa., Pagedar NA; University of Iowa Carver College of Medicine, Department of Otolaryngology - Head and Neck Surgery, University of Iowa, Iowa City, Iowa., Sperry SM; University of Iowa Carver College of Medicine, Department of Otolaryngology - Head and Neck Surgery, University of Iowa, Iowa City, Iowa., Matt B; University of Iowa College of Public Health & the Iowa Cancer Registry, Iowa City, Iowa., Platz C; University of Iowa College of Public Health & the Iowa Cancer Registry, Iowa City, Iowa., Lynch CF; University of Iowa College of Public Health & the Iowa Cancer Registry, Iowa City, Iowa.
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2018 Oct; Vol. 40 (10), pp. 2199-2209. Date of Electronic Publication: 2018 Jun 22.
DOI: 10.1002/hed.25314
Abstrakt: Background: Surveillance, Epidemiology, and End Results Cancer Registries (SEER) began collecting human papillomavirus (HPV) status for upper aerodigestive tract cancers in 2010. However, classification of p16-testing was not included in the Collaborative Stage coding guidelines, potentially leading to inconsistent coding.
Methods: The HPV values for Iowa patients with oropharyngeal cancers (n = 824) were recoded based on modified guidelines that included p16 test results, and compared with the original guidelines.
Results: Forty percent of patients were recoded to a different value, and the HPV testing rate increased from 45% to 55%; 56% received p16-testing only. Of those originally coded as HPV-type 16 (n = 187), 89% were recoded to HPV-not otherwise specified (NOS). When comparing high-level positive/negative/not done categories, original coding captured 81% of patients with HPV-positive cancers.
Conclusion: p16 was the most common HPV test but was inconsistently coded as HPV-testing. p16-positivity was also erroneously equated with HPV-type 16. Adding a separate p16 variable would improve consistency and accuracy of HPV coding.
(© 2018 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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