Memory loss and memory reorganization patterns in temporal lobe epilepsy patients undergoing anterior temporal lobe resection, as demonstrated by pre-versus post-operative functional MRI.

Autor: Limotai C; Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada; Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Chulalongkorn Comprehensive Epilepsy Center of Excellence (CCEC), King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand., McLachlan RS; Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada., Hayman-Abello S; Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada., Hayman-Abello B; Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada., Brown S; Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada., Bihari F; Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada., Mirsattari SM; Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada; Department of Medical Imaging, Western University, London, Ontario, Canada; Department of Medical Biophysics, Western University, London, Ontario, Canada; Department of Psychology, Western University, London, Ontario, Canada. Electronic address: smirsat2@uwo.ca.
Jazyk: angličtina
Zdroj: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2018 Sep; Vol. 55, pp. 38-44. Date of Electronic Publication: 2018 Jun 20.
DOI: 10.1016/j.jocn.2018.06.020
Abstrakt: This study was aimed to longitudinally assess memory function and whole-brain memory circuit reorganization in patients with temporal lobe epilepsy (TLE) by comparing activation potentials before versus after anterior temporal lobe (ATL) resection. Nineteen patients with medically-intractable TLE (10 left TLE, 9 right TLE) and 15 healthy controls were enrolled. Group analyses were conducted pre- and post-ATL of a novelty complex scene-encoding paradigm comparing areas of blood oxygen-level-dependent (BOLD) signal activations on functional magnetic resonance imaging (fMRI). None of the pre-operative patient characteristics we studied predicted the extent of pre- to post-operative memory loss. On fMRI, extra-temporal activations were detected pre-operatively in both LTLE and RTLE, particularly in the frontal lobe. Greater activations also were noted in the contralateral hippocampus and parahippocampus in both groups. Performing within-subject comparisons, post-op relative to pre-op, pronounced ipsilateral activations were identified in the left parahippocampal gyrus in LTLE, versus the right middle temporal gyrus in RTLE patients. Memory function was impaired pre-operatively but declined after ATL resection in both RTLE and LTLE patients. Post-operative fMRI results indicate possible functional adaptations to ATL loss, primarily occurring within the left parahippocampal gyrus versus right middle temporal gyrus in LTLE versus RTLE patients, respectively.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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