| Abstrakt: |
Revealed elevated Nt-pro-BNP concentration in 11% of healthy people aged 19-24 years and 22% of middle-aged (34-55 years); in the case of the metabolic syndrome increasing Nt-pro-BNP concentration in blood is set to 90%. Elevated levels of Nt-pro-BNP in peripheral blood occurs with increasing age; set higher peptide concentration in women. Inhibition of lymphoproliferation and differentiation of lymphocytes with increasing content of Nt-pro-BNP in blood is associated with deficiency of IL-2 content due to increased concentration and IL-10. Immunosuppressive effect of IL-10 appears more at innate immune reactions decrease blood levels of naive T-lymphocytes CD45RA+, natural killer cells, T cell adhesion receptor (CD56+) and adhesion receptor ligand (CD62L+). To prevent loss of cell-cell pool, the effect is activated Nt-pro-BNP. No statistically significant correlation between increased Nt-pro-BNP concentration in blood and the content of serum IgM, IgG, IgA, IgE, IL-6, TNF-α, IFN-γ, CEC Clq and C3d, as well as glucose, hemoglobin, transferrin, iron and free fatty acids in healthy people. |
