Pace of movement: the role of single neurons in the subthalamic nucleus.

Autor:	Tankus A; 1Functional Neurosurgery Unit.; 2Center for Study of Movement, Cognition, and Mobility.; 3Department of Neurology and Neurosurgery, Sackler Faculty of Medicine, and.; 4Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Mirelman A; 2Center for Study of Movement, Cognition, and Mobility.; 3Department of Neurology and Neurosurgery, Sackler Faculty of Medicine, and.; 4Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Giladi N; 3Department of Neurology and Neurosurgery, Sackler Faculty of Medicine, and.; 4Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; 5Department of Neurology, Tel Aviv Sourasky Medical Center., Fried I; 1Functional Neurosurgery Unit.; 3Department of Neurology and Neurosurgery, Sackler Faculty of Medicine, and.; 6Department of Neurosurgery, University of California, Los Angeles, California., Hausdorff JM; 2Center for Study of Movement, Cognition, and Mobility.; 4Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; 7Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; and.; 8Rush Alzheimer's Disease Center and.; 9Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois.
Jazyk:	angličtina
Zdroj:	Journal of neurosurgery [J Neurosurg] 2018 Jun 22; Vol. 130 (6), pp. 1835-1840. Date of Electronic Publication: 2018 Jun 22 (Print Publication: 2019).
DOI:	10.3171/2018.1.JNS171859
Abstrakt:	Objective: The ability to modulate the pace of movement is a critical factor in the smooth operation of the motor system. The authors recently described distinct and overlapping representations of movement kinematics in the subthalamic nucleus (STN), but it is still unclear how movement pace is modulated according to the demands of the task at the neuronal level in this area. The goal of this study was to clarify how different movement paces are being controlled by neurons in the STN. Methods: The authors performed direct recording of the electrical activity of single neurons in the STN of neurosurgical patients with Parkinson's disease undergoing implantation of a deep brain stimulator under local anesthesia while the patients performed repetitive foot and hand movements intraoperatively at multiple paces. Results: A change was observed in the neuronal population controlling the movement for each pace. The mechanism for switching between these controlling populations differs for hand and foot movements. Conclusions: These findings suggest that disparate schemes are utilized in the STN for neuronal recruitment for motor control of the upper and lower extremities. The results indicate a distributed model of motor control within the STN, where the active neuronal population changes when modifying the task condition and pace.
Databáze:	MEDLINE
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