[State of tolerance of multi resistant tuberculosis treatment (Burkina Faso)].

Autor:	Ouédraogo SM; Service de médecine interne CHU Souro Sanou, Bobo-Dioulasso, Burkina Faso.; Institut Supérieur des Sciences de la Santé, Bobo-Doiulasso, Burkina Faso., Sondo KA; Unité de Formation et de Recherche en Sciences de la Santé, Ouagadougou, Burkina Faso.; Service de maladies infectieuses CHU Yalgado Ouédraogo, Ouagadougou, Burkina Faso., Ouédraogo AR; Service de pneumo-phtisiologie, CHU Yalgado Ouédraogo, Ouagadougou, Burkina Faso., Ouédraogo G; Service de pneumo-phtisiologie, CHU Yalgado Ouédraogo, Ouagadougou, Burkina Faso.; Unité de Formation et de Recherche en Sciences de la Santé, Ouagadougou, Burkina Faso., Badoum G; Service de pneumo-phtisiologie, CHU Yalgado Ouédraogo, Ouagadougou, Burkina Faso.; Unité de Formation et de Recherche en Sciences de la Santé, Ouagadougou, Burkina Faso., Boncoungou K; Service de pneumo-phtisiologie, CHU Yalgado Ouédraogo, Ouagadougou, Burkina Faso.; Unité de Formation et de Recherche en Sciences de la Santé, Ouagadougou, Burkina Faso., Bambara AT; Unité de Formation et de Recherche en Sciences de la Santé, Ouagadougou, Burkina Faso.; Service d'hématologie et de cancérologie CHU Yalgado Ouédraogo, Ouagadougou, Burkina Faso., Koumbem B; Service de pneumo-phtisiologie, CHU Yalgado Ouédraogo, Ouagadougou, Burkina Faso., Savadogo M; Unité de Formation et de Recherche en Sciences de la Santé, Ouagadougou, Burkina Faso.; Service de maladies infectieuses CHU Yalgado Ouédraogo, Ouagadougou, Burkina Faso., Zoungrana J; Institut Supérieur des Sciences de la Santé, Bobo-Doiulasso, Burkina Faso.; Service de maladies infectieuses CHU Souro Sanou, Bobo-Dioulasso, Burkina Faso., Kyelem CG; Service de médecine interne CHU Souro Sanou, Bobo-Dioulasso, Burkina Faso.; Institut Supérieur des Sciences de la Santé, Bobo-Doiulasso, Burkina Faso., Maïga S; Service de pneumo-phtisiologie, CHU Yalgado Ouédraogo, Ouagadougou, Burkina Faso., Djibril MA; Service de réanimation médicale, CHU Sylvanus Olympio, Lomé., Ouédraogo M; Service de pneumo-phtisiologie, CHU Yalgado Ouédraogo, Ouagadougou, Burkina Faso.; Unité de Formation et de Recherche en Sciences de la Santé, Ouagadougou, Burkina Faso., Drabo YJ; Unité de Formation et de Recherche en Sciences de la Santé, Ouagadougou, Burkina Faso.; Service de médecine interne CHU yalgado ouédraogo, Ouagadougou, Burkina Faso.
Jazyk:	francouzština
Zdroj:	Le Mali medical [Mali Med] 2015; Vol. 30 (4), pp. 39-45.
Abstrakt:	Objectives: Estimate the tolerance of antituberculous drugs prescribed in the treatment of multi resistant tuberculosis on patients followed in the service of Pneumology of the University hospital of Yalgado Ouedraogo. Patients and Methods: It was a retrospective and prospective longitudinal investigation. The files of patients allowed to inform the questionnaire for the retrospective phase (2010-2011), the follow-up of patients during the prospective phase (2011-2013) allowed for data collection. All the patients under antituberculous treatment of 2nd line between January 1st, 2010 and the August 31st, 2013 were included. Results: 71 cases of multi resistant tuberculosis (MRT) were included. The sex-ratio was 3.4. The age bracket from 30 to 39 was the most represented (39.4 %). A notion of tubercular contage was found in 18 (25.3%) patients. All MRT patient had histories of treatment including aminoside lasting more than 2 months. Intolerance of the treatment was reported in 57 patients. Intolerance predominated in 30 to 39 years olds and in Tuberculosis/HIV co-infected patients. The neurological (47.9%) and psychiatric (47.9%) infringements were the most represented. Vestibulocochlear impact was seen in 42.3% of cases with 18.3% reporting of total deafness. Conclusion: The intolerance of the antituberculous treatment of the second line is real focus for clinicians. Shorter timeframes would avoid certain therapeutic modifications thought to be at the origin of failures. (Le comitée de rédaction se réserve le droit de revoyer aux auteurs avant toute soumission à l'avis des lecteurs les manuscrits qui ne seraient pas conformes à ces modalités de présentation. En outre il leur conseille de sonserver un examplaire du manuscrit, des figures et des tableaux.)
Databáze:	MEDLINE
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