[Effects of CHL1 deficiency,a cell adhesion molecule,on the inflammatory bowel disease].

Autor:	Wang XM; Department of Brain Science and Stress, Institute of Cognition and Brain Sciences, Beijing 100850., Zhao T; Department of Brain Science and Stress, Institute of Cognition and Brain Sciences, Beijing 100850., Cheng X; Department of Brain Science and Stress, Institute of Cognition and Brain Sciences, Beijing 100850., Guo N; Department of Brain Science and Stress, Institute of Cognition and Brain Sciences, Beijing 100850., Zhu LL; Department of Brain Science and Stress, Institute of Cognition and Brain Sciences, Beijing 100850., Shi M; Jiangsu Province Cancer Biotherapy Institute, Xuzhou 221004, China., Wu KW; Department of Brain Science and Stress, Institute of Cognition and Brain Sciences, Beijing 100850.
Jazyk:	čínština
Zdroj:	Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology [Zhongguo Ying Yong Sheng Li Xue Za Zhi] 2018 Jan 08; Vol. 34 (1), pp. 4-7.
DOI:	10.12047/j.cjap.5567.2018.002
Abstrakt:	Objective: To investigate the effects of deficiency of CHL1 in inflammatory bowel disease (IBD). Methods: Dextran Sulfate Sodium (DSS)-induced colitis model was used to study the effects of deficiency of CHL1 on the development of IBD. Ten CHL1(+/+) mice in C57/BL6 background were randomly divided into CHL1(+/+) group and DSS-induced CHL1(+/+) group. Ten CHL1(-/-) mice in C57/BL6 background were randomly divided into CHL1(-/-) group and DSS-induced CHL1(-/-) group. DSS-induced CHL1(+/+) group and DSS-induced CHL1(-/-)group were fed with 1.5% DSS for 7 days, and then drinking distilled water for 2 days. CHL1(+/+) group and CHL1(-/-) group as control group were fed with distilled water for 9 days. The changes of weight, survival, fecal blood and the change of colon length in this study were observed. Results: On the 7 th day, the weight of DSS-induced CHL1(-/-) group were reduced significantly, and DSS-induced CHL1(-/-) group had extreme mortality on the 9th day. The fecal blood of DSS-induced CHL1(-/-) group also had higher score than that of DSS-induced CHL1(+/+) group. In the DSS-induced CHL1(-/-) group,the length of colon was shortened obviously. Conclusions: The loss of CHL1 aggravates the development of IBD.
Databáze:	MEDLINE
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