Evaluation of a hydrogel membrane on bone regeneration in furcation periodontal defects in dogs.

Autor:	Struillou X; INSERM, UMR-S 1229, RMeS, Faculty of Dental Surgery, University of Nantes.; Department of Periodontology, Faculty of Dental Surgery, University of Nantes.; Nantes University Hospital, UIC Odontology., Fruchet A; INSERM, UMR-S 1229, RMeS, Faculty of Dental Surgery, University of Nantes.; Nantes University Hospital, UIC Odontology., Rakic M; INSERM, UMR-S 1229, RMeS, Faculty of Dental Surgery, University of Nantes.; Institute for Biological Research 'Sinisa Stankovic', University of Belgrade., Badran Z; INSERM, UMR-S 1229, RMeS, Faculty of Dental Surgery, University of Nantes.; Department of Periodontology, Faculty of Dental Surgery, University of Nantes.; Faculty of Dentistry, Mcgill University., Rethore G; INSERM, UMR-S 1229, RMeS, Faculty of Dental Surgery, University of Nantes.; Nantes University Hospital, UIC Odontology., Sourice S; INSERM, UMR-S 1229, RMeS, Faculty of Dental Surgery, University of Nantes., Fellah BH; ONIRIS, College of Veterinary Medicine, Department of Small Animal Surgery., LE Guehennec L; INSERM, UMR-S 1229, RMeS, Faculty of Dental Surgery, University of Nantes.; Nantes University Hospital, UIC Odontology., Gauthier O; ONIRIS, College of Veterinary Medicine, Department of Small Animal Surgery., Weiss P; INSERM, UMR-S 1229, RMeS, Faculty of Dental Surgery, University of Nantes.; Nantes University Hospital, UIC Odontology., Soueidan A; INSERM, UMR-S 1229, RMeS, Faculty of Dental Surgery, University of Nantes.; Department of Periodontology, Faculty of Dental Surgery, University of Nantes.; Nantes University Hospital, UIC Odontology.
Jazyk:	angličtina
Zdroj:	Dental materials journal [Dent Mater J] 2018 Sep 30; Vol. 37 (5), pp. 825-834. Date of Electronic Publication: 2018 Jun 20.
DOI:	10.4012/dmj.2017-238
Abstrakt:	The aim of the study was to evaluate bone regeneration using a canine model with surgically created periodontal defects filled for 12 weeks using a stratified biomaterial consisting in a biphasic calcium phosphate (BCP) covered with a crosslinking hydrogel acting as polymer membrane of silated hydroxypropyl methylcellulose (Si-HPMC) as the tested new concept. Bilateral, critical-sized, defects were surgically created at the mandibular premolar teeth of six adult beagle dogs. The defects were randomly allocated and: (i) left empty for spontaneous healing or filled with: (ii) BCP and a collagen membrane; (iii) BCP and hydrogel Si-HPMC membrane. At 12 weeks, the experimental conditions resulted in significantly enhanced bone regeneration in the test BCP/Si-HPMC group. Within the limits of this study, we suggest that the hydrogel Si-HPMC may act as an occlusive barrier to protect bone area from soft connective tissue invasion and then effectively contribute to enhance bone regeneration.
Databáze:	MEDLINE
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