| Autor: |
Vallano ML, Buckholz TM, DeLorenzo RJ |
| Jazyk: |
angličtina |
| Zdroj: |
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1985 Aug 15; Vol. 130 (3), pp. 957-63. |
| DOI: |
10.1016/0006-291x(85)91708-5 |
| Abstrakt: |
A protein fraction containing neurofilaments was prepared from rat brain cytosol by differential centrifugation and gel filtration chromatography. These preparations were enriched for a calcium/calmodulin-dependent kinase activity that phosphorylated endogenous neurofilament proteins. The enzyme incorporated approximately 1 mol PO4/mol of each neurofilament triplet polypeptide. These data suggest that a calmodulin-dependent kinase may mediate some of the effects of calcium on cytoskeletal function by phosphorylation of neurofilament proteins. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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