Defens-IN! Human α-Defensin 5 Acts as an Unwitting Double Agent to Promote Shigella Infection.

Autor: Murphy AG; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK., Maloy KJ; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK. Electronic address: kevin.maloy@path.ox.ac.uk.
Jazyk: angličtina
Zdroj: Immunity [Immunity] 2018 Jun 19; Vol. 48 (6), pp. 1070-1072.
DOI: 10.1016/j.immuni.2018.05.015
Abstrakt: Shigella pathogenesis has confounded researchers for years because of its narrow host selectivity and extraordinary infectious capability. In this issue of Immunity, Xu et al. (2018) identify a cunning mechanism whereby Shigella hijacks human α-defensin 5 to enhance its adhesion and subsequent invasion.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE