Preliminary study about the relationship between estimated training status and RAS polymorphisms on blood pressure and ACE activity in the elderly.

Autor:	Silva RFD; 1 Department of Physical Education, São Paulo State University (UNESP), School of Science, Bauru, Brazil., Lacchini R; 2 School of Nursing of Ribeirão Preto, USP - University of São Paulo, Ribeirão Preto, Brazil., Pinheiro LC; 3 Faculty of Medicine of Ribeirão Preto, USP - University of São Paulo, Ribeirão Preto, Brazil., Dionísio TJ; 4 Bauru School of Dentistry, University of São Paulo, Bauru, Brazil., Jacomini A; 1 Department of Physical Education, São Paulo State University (UNESP), School of Science, Bauru, Brazil., Tanus-Santos JE; 3 Faculty of Medicine of Ribeirão Preto, USP - University of São Paulo, Ribeirão Preto, Brazil., Amaral SL; 1 Department of Physical Education, São Paulo State University (UNESP), School of Science, Bauru, Brazil., Santos CF; 4 Bauru School of Dentistry, University of São Paulo, Bauru, Brazil., Zago AS; 1 Department of Physical Education, São Paulo State University (UNESP), School of Science, Bauru, Brazil.
Jazyk:	angličtina
Zdroj:	Journal of the renin-angiotensin-aldosterone system : JRAAS [J Renin Angiotensin Aldosterone Syst] 2018 Apr-Jun; Vol. 19 (2), pp. 1470320318782622.
DOI:	10.1177/1470320318782622
Abstrakt:	Objective: Polymorphisms of the renin angiotensin system (RAS) are associated with increases in blood pressure (BP). Physical exercise has been considered the main strategy to prevent this increase. This study aimed to investigate the relationship between estimated training status (TS), BP and angiotensin-converting enzyme (ACE) activity in elderly people classified as low or high risk to develop hypertension according to genetic profile. Methods: A total of 155 elderly participants performed the following assessments: general functional fitness index (GFFI), systolic BP (SBP) and diastolic BP (DBP), blood collection for ACE activity and analyses of the RAS polymorphisms. Results: Uncontrolled hypertensive (UHT) participants presented higher values of SBP and DBP compared with normotensive (NT) and controlled hypertensive (CHT) participants. No differences were found in ACE activity and GFFI between groups. In the high risk group, UHT presented higher values of SBP and DBP compared with other groups. CHT presented higher values of SBP compared with NT. Furthermore, UHT presented higher values of ACE activity compared with CHT and lower values of GFFI compared with NT. Conclusion: MDA, TIA and TIC genetic combinations were associated with high risk of developing hypertension while the maintenance of good levels of TS was associated with lower BP values and ACE activity.
Databáze:	MEDLINE
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