Association of human beta-defensin 1 gene polymorphisms with nonsegmental vitiligo.

Autor: Ochoa-Ramírez LA; Faculty of Chemical and Biological Sciences, Autonomous University of Sinaloa, Culiacan, Sinaloa, Mexico., Becerra-Loaiza DS; Faculty of Chemical and Biological Sciences, Autonomous University of Sinaloa, Culiacan, Sinaloa, Mexico., Díaz-Camacho SP; Faculty of Chemical and Biological Sciences, Autonomous University of Sinaloa, Culiacan, Sinaloa, Mexico., Muñoz-Estrada VF; Center of Research and Teaching in Health Sciences (CIDOCS), Autonomous University of Sinaloa, Culiacan, Sinaloa, Mexico., Ríos-Burgueño ER; Center of Research and Teaching in Health Sciences (CIDOCS), Autonomous University of Sinaloa, Culiacan, Sinaloa, Mexico., Prado-Montes de Oca E; Personalized Medicine National Laboratory (LAMPER), Medical and Pharmaceutical Biotechnology, Research Center in Technology and Design Assistance of Jalisco State (CIATEJ), National Council of Science and Technology (CONACYT), Jalisco, Mexico., Rangel-Villalobos H; Molecular Genetics Research Institute, University of Guadalajara (CUCI-UdeG), Ocotlan, Jalisco, Mexico., Velarde-Félix JS; Faculty of Chemical and Biological Sciences, Autonomous University of Sinaloa, Culiacan, Sinaloa, Mexico.; Faculty of Biology, Autonomous University of Sinaloa, Culiacan, Sinaloa, Mexico.; General Hospital of Culiacan, Servicios de Salud Sinaloa, Culiacan, Mexico.
Jazyk: angličtina
Zdroj: Clinical and experimental dermatology [Clin Exp Dermatol] 2019 Apr; Vol. 44 (3), pp. 277-282. Date of Electronic Publication: 2018 Jun 20.
DOI: 10.1111/ced.13697
Abstrakt: Background: Vitiligo is a pigmentation disorder of autoimmune aetiology. Polymorphisms in beta-defensin genes have been linked to a predisposition to some autoimmune disorders.
Aim: To evaluate the role of polymorphisms in DEFB1, the gene encoding for human beta-defensin (HBD)-1 and its 5' untranslated region in nonsegmental vitiligo.
Methods: In total, 354 participants [171 patients with non-segmental vitiligo and 183 age and sex-matched healthy controls (HCs)], were genotyped by the PCR-restriction fragment length polymorphism (RFLP) method. For 80 of these individuals (40 patients and -40 HCs) serum HBD-1 was also measured by ELISA.
Results: The -44 G allele, CG genotype and GGG haplotype increased the risk for vitiligo (P < 0.02 in all cases), whereas the -20 AA genotype seems to be protective (P = 0.04). Serum HBD-1 levels were lower in patients with vitiligo than in HCs (P < 0.01), as well as in patients with active vitiligo compared with those with stable vitiligo and with HCs (P < 0.05 in both cases), CONCLUSION: Our results suggest that HBD-1 and its gene polymorphisms may modulate vitiligo susceptibility and/or disease activity. This is the first report, to our knowledge, of the association of serum HBD-1 levels and DEFB1 gene polymorphisms with vitiligo.
(© 2018 British Association of Dermatologists.)
Databáze: MEDLINE
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