Different Pathophysiology of Gastritis in East and West? A Western Perspective.
| Autor: | Wirth HP; GastroZentrumKreuzlingen, Kreuzlingen, Switzerland., Yang M; GastroZentrumKreuzlingen, Kreuzlingen, Switzerland. |
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| Jazyk: | angličtina |
| Zdroj: | Inflammatory intestinal diseases [Inflamm Intest Dis] 2016 Oct; Vol. 1 (3), pp. 113-122. Date of Electronic Publication: 2016 May 14. |
| DOI: | 10.1159/000446300 |
| Abstrakt: | Background: Gastritis results from multifactorial gastric mucosal injury. Helicobacter pylori (Hp) is the main cause, and associated diseases have typical underlying patterns of gastritis. Gastric ulcer and gastric cancer (GC) develop from chronic atrophic corpus gastritis (CAG) which therefore represents the most important pattern. GC incidences in East Asia are substantially higher than elsewhere, and this should be also reflected by higher prevalences of CAG and characteristic differences in pathophysiology compared to the West. Summary: The few available comparative studies of gastritis in Eastern and Western patients are summarized. The main pathogenic factors of gastritis are discussed together with their limitations to explain local differences in disease outcome. Emphasis was put to also include less well-established pathogenic host and environmental factors of possible impact. Conclusions: CAG is more prevalent in East Asian areas with high GC incidences than the West. Geographic heterogeneity of associated diseases is due to differences in Hp prevalence and virulence as well as modulating host and environmental factors. The following may contribute to the higher burden of CAG in the East: ABD type of CagA with vacA s1 and babA2 alleles of Hp , host Lewis(b) expression in sej/sej nonsecretors, H. heilmannii , low parietal cell mass, high sodium and nitrate intake, preferences in vegetable and fruit consumption, cigarette smoking, air pollution, alcohol. Conversely, green tea, nonfermented soy products and rice may confer protective effects. Hp is on the decline, but also in a world cleared from this bacterium, differences in host genetics will continue to modify gastric disease outcome together with maintained customs as part of cultural diversity. |
| Databáze: | MEDLINE |
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