Seroprevalence of dengue in school children in Mexico ages 6-17 years, 2016.

Autor:	Amaya-Larios IY; Instituto Nacional de Salud Publica. Centro de Investigaciones sobre Enfermedades Infecciosas, Cuernavaca, Morelos. CP, Mexico., Rojas-Russell M; Universidad Nacional Autonoma de Mexico, Centro de Investigaciones en Politica, Poblacion y Salud, Mexico City, CP, Mexico., López-Cervantes M; Secretaria de Salud, Mexico City, CP, Mexico., Castro-Porras L; Universidad Nacional Autonoma de Mexico, Centro de Investigaciones en Politica, Poblacion y Salud, Mexico City, CP, Mexico., Castro-Borbonio MV; Universidad Nacional Autonoma de Mexico, Centro de Investigaciones en Politica, Poblacion y Salud, Mexico City, CP, Mexico., Sarti E; Sanofi Pasteur, Mexico City, CP, Mexico., Puentes-Rosas E; Sanofi Pasteur, Mexico City, CP, Mexico., Tirado-Gómez LL; Universidad Nacional Autonoma de Mexico, Centro de Investigaciones en Politica, Poblacion y Salud, Mexico City, CP, Mexico., Olaíz-Fernandez G; Universidad Nacional Autonoma de Mexico, Centro de Investigaciones en Politica, Poblacion y Salud, Mexico City, CP, Mexico., Ramos-Castañeda J; Instituto Nacional de Salud Publica. Centro de Investigaciones sobre Enfermedades Infecciosas, Cuernavaca, Morelos. CP, Mexico.; Center for Tropical Diseases, University of Texas-Medical Branch, Center for Tropical Diseases, Galveston, Texas, USA.
Jazyk:	angličtina
Zdroj:	Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 2018 May 01; Vol. 112 (5), pp. 223-229.
DOI:	10.1093/trstmh/try046
Abstrakt:	Background: Dengue is the most important arboviral disease in the world. Seroprevalence has been proposed as a marker of endemicity, however, studies are scarce. Methods: We conducted a cross-sectional, stratified cluster, random sample study to measure the seroprevalence of antibodies to dengue virus (DENV) in Mexico. The target population was school children ages 6-17 y from 22 endemic states in Mexico, clustered in four regions: Pacific, South-Central, Southeast and Low. Results: A total of 2134 subjects provided blood samples for immunoglobulin G antibody detection in serum by enzyme-linked immunosorbent assay. Overall, the seroprevalence of antibodies against DENV was 33.5% (95% confidence interval [CI] 27.5 to 40.1). The Southeast had the highest regional seroprevalence, reaching 70.9% (95% CI 60.3 to 79.7). Seroprevalence was higher in older children in the Southeast region: 62.1% (95% CI 46.9 to 75.2) in children 6-8 y and 82.6% (95% CI 73.8 to 88.9) in 13-17 years old (y). However, this was not consistent in all regions. Seroprevalence was associated with dengue incidence. Conclusions: DENV seroprevalence in Mexico was found to be heterogeneous at the country, regional and state levels. Seroprevalence was linked to long-term exposure and did not adequately reflect recent patterns of transmission, suggesting that utilization of a single epidemiological indicator to define endemic regions should be avoided.
Databáze:	MEDLINE
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