Effects of intratesticular injection of zinc-based solution in rats in combination with anti-inflammatory and analgesic drugs during chemical sterilization.

Autor: de Macêdo SRB; Department of Veterinary Medicine, Federal Rural University of Pernambuco, Recife, Brazil., de Lima LAR; Department of Veterinary Medicine, Federal Rural University of Pernambuco, Recife, Brazil., de Torres SM; Department of Veterinary Medicine, Federal Rural University of Pernambuco, Recife, Brazil., de Oliveira VVG; Department of Veterinary Medicine, Federal Rural University of Pernambuco, Recife, Brazil., de Morais RN; Department of Physiology, Federal University of Paraná, Curitiba, Paraná, Brazil., Peixoto CA; Laboratory of Ultrastructure, Aggeu Magalhães Research Center (CPqAM), Recife, Pernambuco, Brazil., Tenorio BM; Department of Morphology, Federal University of Paraíba, João Pessoa, Paraíba, Brazil., Junior VADS; Department of Veterinary Medicine, Federal Rural University of Pernambuco, Recife, Brazil.
Jazyk: angličtina
Zdroj: Veterinary world [Vet World] 2018 May; Vol. 11 (5), pp. 649-656. Date of Electronic Publication: 2018 May 19.
DOI: 10.14202/vetworld.2018.649-656
Abstrakt: Aim: Chemical sterilization is a non-surgical method of contraception based on compounds injected into the testis to induce infertility. However, these injections can cause discomfort and pain able to impair the recovery of animals after this treatment. The objective of this study was to investigate if anti-inflammatories or pain relievers inhibited the sterilizing effect of zinc gluconate-based solution on the testis.
Materials and Methods: Adult rats were treated in groups: G1 (control), G2 (dimethyl sulfoxide + dipyrone); G3 (dipyrone/zinc); G4 (dipyrone + celecoxib/zinc); G5 (dipyrone + meloxicam/zinc), and G6 (dipyrone + dexamethasone/zinc) in a single dose per day during 7 days. Animals were analyzed at 7, 15, and 30 days after treatments.
Results: The zinc-induced a widespread testicular degeneration and decreased testosterone levels even in combination with anti-inflammatories or pain relievers. Testis, epididymis, prostate, and seminal vesicle had a weight reduction. The anti-inflammatory effect of dexamethasone interfered in the desired action of zinc gluconate in the 1 st 15 days and celecoxib up to 7 days.
Conclusion: Meloxicam plus dipyrone did not impair the chemical sterilization based on zinc gluconate, and it can be used to reduce nociceptive effects in animals after chemical sterilization.
Databáze: MEDLINE
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