Changes in white matter in mice resulting from low-frequency brain stimulation.
| Autor: | Piscopo DM; Department of Biology, University of Oregon, Eugene, OR 97403., Weible AP; Institute of Neuroscience, University of Oregon, Eugene, OR 97403., Rothbart MK; Department of Psychology, University of Oregon, Eugene, OR 97403., Posner MI; Institute of Neuroscience, University of Oregon, Eugene, OR 97403; mposner@uoregon.edu.; Department of Psychology, University of Oregon, Eugene, OR 97403., Niell CM; Department of Biology, University of Oregon, Eugene, OR 97403.; Institute of Neuroscience, University of Oregon, Eugene, OR 97403. |
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| Jazyk: | angličtina |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Jul 03; Vol. 115 (27), pp. E6339-E6346. Date of Electronic Publication: 2018 Jun 18. |
| DOI: | 10.1073/pnas.1802160115 |
| Abstrakt: | Recent reports have begun to elucidate mechanisms by which learning and experience produce white matter changes in the brain. We previously reported changes in white matter surrounding the anterior cingulate cortex in humans after 2-4 weeks of meditation training. We further found that low-frequency optogenetic stimulation of the anterior cingulate in mice increased time spent in the light in a light/dark box paradigm, suggesting decreased anxiety similar to what is observed following meditation training. Here, we investigated the impact of this stimulation at the cellular level. We found that laser stimulation in the range of 1-8 Hz results in changes to subcortical white matter projection fibers in the corpus callosum. Specifically, stimulation resulted in increased oligodendrocyte proliferation, accompanied by a decrease in the g-ratio within the corpus callosum underlying the anterior cingulate cortex. These results suggest that low-frequency stimulation can result in activity-dependent remodeling of myelin, giving rise to enhanced connectivity and altered behavior. Competing Interests: The authors declare no conflict of interest. |
| Databáze: | MEDLINE |
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