Depression among multidrug-resistant tuberculosis patients in Punjab, Pakistan: a large cross-sectional study.

Autor:	Walker IF; Nuffield Centre for International Health and Development, University of Leeds, Leeds, UK., Khan AM; Association for Social Development, Islamabad., Khan AM; Association for Social Development, Islamabad., Khan NM; National TB Control Programme Islamabad, Pakistan., Ayub RM; National TB Control Programme Islamabad, Pakistan., Ghias KN; Association for Social Development, Islamabad., Walley JD; Nuffield Centre for International Health and Development, University of Leeds, Leeds, UK.
Jazyk:	angličtina
Zdroj:	The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [Int J Tuberc Lung Dis] 2018 Jul 01; Vol. 22 (7), pp. 773-778.
DOI:	10.5588/ijtld.17.0788
Abstrakt:	Background and Objectives: Depression is likely to be a factor in the low global rates of successful treatment for multidrug-resistant tuberculosis (MDR-TB) due to poor adherence to treatment. We aimed to estimate the prevalence of depression among patients being treated for MDR-TB in Pakistan, explore rates of depression over the course of treatment and identify risk factors for depression. Design: This cross-sectional study analysed health care service data from 12 treatment sites following a single screening event using the Patient Health Questionnaire 9 (PHQ-9). Logistic regression models were used to identify associations. Results: Data were collected from 1279 patients with MDR-TB. The proportion of MDR-TB patients with depression was 42.8% (95%CI 40.1-45.5). Rates of depression varied according to duration of treatment, with the highest proportion (53.2%) found in those who were in months 10-12 of treatment. The odds of depression in women were higher than for men (adjusted odds ratio [aOR] 1.84, 95%CI 1.46-2.33). The odds of depression were higher in patients living in concrete-built houses than in those living in mud-built houses (aOR 1.37, 95%CI 1.03-1.82). Conclusion: Depression is common in MDR-TB patients, and should be screened for and treated within MDR-TB treatment programmes.
Databáze:	MEDLINE
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