| Autor: |
Foulds G, Knirsch AK, Stankewich JP, Weidler DR |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of clinical pharmacology research [Int J Clin Pharmacol Res] 1985; Vol. 5 (2), pp. 79-86. |
| Abstrakt: |
The kinetics of co-administered ampicillin plus sulbactam were examined at doses being used in clinical trials of this combination of a beta-lactam antibiotic (ampicillin) and a beta-lactamase inhibitor (sulbactam). Following 15-min infusion of 2 g ampicillin plus 1 g sulbactam, peak serum concentrations of 120 micrograms/ml ampicillin and 60 micrograms/ml sulbactam were observed. The half-life was approximately one hour for both drugs. Approximately 75% of the dose of sulbactam and ampicillin was recovered in urine. The data fit a two-compartment pharmacokinetic model. Intramuscular administration of 1 g ampicillin plus 0.5 g sulbactam produced mean peak concentrations of 18 micrograms/ml ampicillin plus 13 micrograms/ml sulbactam. Estimates of variability of the data in normal male subjects are provided to serve as references for clinical trials. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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