Characteristics of Obstructive Sleep Apnea Across the Spectrum of Glucose Tolerance in Obese Adolescents.
| Autor: | Hannon TS; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, United States., Watson SE; Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY, United States., Jalou HE; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, United States., Chakravorty S; Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA, United States., Mather KJ; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States., Arslanian SA; Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA, United States. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2018 Jun 01; Vol. 9, pp. 281. Date of Electronic Publication: 2018 Jun 01 (Print Publication: 2018). |
| DOI: | 10.3389/fendo.2018.00281 |
| Abstrakt: | Background: It is not known if dysglycemia and sleep-disordered breathing are linked in adolescents, as in adults. Objective: To perform a pilot study evaluating measures of sleep-disordered breathing across the spectrum of glucose tolerance in obese adolescents. We hypothesized that dysglycemia would be associated with sleep-disordered breathing. Participants/methods: This was a prospective, cross-sectional clinical pilot study that included 57 adolescents [body mass index (BMI) 38.9 ± 8.4 kg/m 2 ] aged 12-18 years (14.5 ± 1.6) with normal glucose tolerance (NGT), or dysglycemia [impaired glucose tolerance (IGT) or type 2 diabetes (T2D)]. Measures: Anthropometrics, overnight polysomnogram, and oral glucose tolerance tests were performed. Participant characteristics and outcome measures were compared by glucose tolerance status. Correlational analyses were conducted to assess the associations between variables of interest. Results: Participants with dysglycemia ( n = 21) were not different from those with NGT ( n = 36) for BMI, waist circumference, body fat, or sleep characteristics. Nocturnal oxygen desaturation was associated with higher BMI ( r = -0.334, p = 0.012). The apnea-hypopnea index (AHI) was not associated with physical and metabolic parameters. Although participants with dysglycemia tended to have higher AHIs (median 3.2, 2.2, and 1.6 events/h for T2D, IGT, and NGT, respectively), there was not a linear relationship between measures of glycemia and AHI. Conclusion: Further study with a larger proportion of youth with prediabetes and T2D is necessary to determine whether evaluation for sleep-disordered breathing is uniformly warranted. |
| Databáze: | MEDLINE |
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