Low-Grade Malignant Peripheral Nerve Sheath Tumor Mimicking Schwannoma: Role and Importance of Trimethylated H3K27M Staining.

Autor: Gilder HE; Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA., Puffer RC; Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA., Spinner RJ; Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA., Raghunathan A; Department of Pathology, Mayo Clinic, Rochester, Minnesota, USA., Bydon M; Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA. Electronic address: bydon.mohammad@mayo.edu.
Jazyk: angličtina
Zdroj: World neurosurgery [World Neurosurg] 2018 Sep; Vol. 117, pp. 178-181. Date of Electronic Publication: 2018 Jun 14.
DOI: 10.1016/j.wneu.2018.06.035
Abstrakt: Background: It is important to differentiate low-grade malignant peripheral nerve sheath tumors (MPNSTs) from benign nerve sheath tumors as MPNSTs may require a more aggressive treatment strategy during and after initial resection. Loss of expression of the trimethyl histone H3 at the Lys27 position (H3K27-me3) has recently been described in MPNSTs and may help distinguish this tumor from pathologic mimics.
Methods: A 43-year-old woman presented with symptoms of radiculopathy and a history of pelvic radiation for cervical cancer 7 years prior. Imaging and surgical pathology were initially consistent with an L5 schwannoma including spindle morphology without mitoses and retained S100 expression. After an aggressive recurrence 11 months later, pathology was consistent with high-grade MPNST including heightened mitotic activity and loss of S100 expression.
Results: After the identification of MPNST, H3K27M me3 immunostaining was applied to both the initial and recurrent pathologic specimens. The initial specimen demonstrated patchy loss of H3K27M me3 expression, more consistent with low-grade MPNST than schwannoma.
Conclusion: This case highlights the role of H3K27M me3 immunostaining to help differentiate MPNSTs that may mimic more benign nerve sheath tumors, especially in patients who have a history of radiation to the region in question.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE