Development of tactile sensory circuits in the CNS.

Autor: Iwasato T; National Institute of Genetics, Mishima, Japan; Department of Genetics, SOKENDAI, Mishima, Japan., Erzurumlu RS; Department of Anatomy and Neurobiology, School of Medicine, University of Maryland, Baltimore, MD, USA. Electronic address: rerzurumlu@som.umaryland.edu.
Jazyk: angličtina
Zdroj: Current opinion in neurobiology [Curr Opin Neurobiol] 2018 Dec; Vol. 53, pp. 66-75. Date of Electronic Publication: 2018 Jun 13.
DOI: 10.1016/j.conb.2018.06.001
Abstrakt: Molecular identification of neuronal types and genetic and imaging approaches to characterize their properties reveal morphological, physiological and dynamic aspects of sensory circuit development. Here we focus on the mouse tactile sensory circuitry, with particular emphasis on the main trigeminal pathway that connects the whiskers, the major tactile organ in rodents, to the neocortex. At each level of this pathway, neurogenesis, axonal elongation, pathfinding, target recognition and circuit reorganization including dendritic refinement of cortical layer 4 neurons occur contemporaneously and a multitude of molecular signals are used in differing combinations. We highlight recent advances in development of tactile circuitry and note gaps in our understanding.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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