Selective modification of fluciclovine ( 18 F) transport in prostate carcinoma xenografts.

Autor: Tade FI; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA., Wiles WG 4th; Winship Cancer Institute, Atlanta, GA, USA., Lu G; Department of Otolaryngology, Stanford University, Stanford, CA, USA., Bilir B; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA., Akin-Akintayo O; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA., Lee JS; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA., Patil D; Winship Cancer Institute, Atlanta, GA, USA., Yu W; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA., Ormenisan Gherasim C; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA., Fei B; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA., Moreno CS; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA., Osunkoya AO; Winship Cancer Institute, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.; Department of Urology, Emory University, Atlanta, GA, USA., Teoh EJ; Department of Oncology, Cancer Imaging Centre Oxford, University of Oxford, Oxford, UK., Oka S; Research Center, Nihon Medi-Physics Co., Ltd., Chiba, 299-0266, Japan., Okudaira H; Research Center, Nihon Medi-Physics Co., Ltd., Chiba, 299-0266, Japan., Goodman MM; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA., Schuster DM; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA. dschust@emory.edu.
Jazyk: angličtina
Zdroj: Amino acids [Amino Acids] 2018 Sep; Vol. 50 (9), pp. 1301-1305. Date of Electronic Publication: 2018 Jun 15.
DOI: 10.1007/s00726-018-2600-0
Abstrakt: We investigated if previously demonstrated inhibition of fluciclovine ( 18 F) in vitro could be replicated in a PC3-Luc xenograft mouse model. Following intratumoral injection of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), alpha-(methylamino)isobutyric acid (MeAIB) or saline, fluciclovine PET tumor-to-background activity was 43.6 (± 5.4)% and 25.3 (± 5.2)% lower in BCH (n = 6) and MeAIB (n = 5) injected PC3 Luc xenografts, respectively, compared to saline-injected controls (n = 2). Partial inhibition of fluciclovine uptake by BCH and MeAIB can be demonstrated in vivo similar to previous in vitro modeling.
Databáze: MEDLINE
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